Results 51 to 60 of about 312,025 (347)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

216 Jewish Hospital of St. Louis [PDF]

, 1965
https://digitalcommons.wustl.edu/bjc_216/1066/thumbnail ...

core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray

Arthritis Research & Therapy
Background Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify biomarkers for detecting SSc pulmonary complications that are mild and ...
Jing Huang, Honglin Zhu, Sijia Liu, Mengtao Li, Yisha Li, Hui Luo, Xiaoxia Zuo   +6 more
doaj   +1 more source

New insight into "allograft acceptance" and tolerance [PDF]

, 1998
Discovery of microchimerism in kidney and liver transplantation provided an important framework for a better understanding of allograft acceptance, for analysis of managment problems and for therapeutically oriented transplanted research.
Starzl, TE
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Clinical characteristics of patients with a family history of psoriasis: an observational epidemiological study in Chinese Han population

Frontiers in Medicine
IntroductionPsoriasis, a chronic inflammatory skin disease, is believed to be influenced by both genetic and environmental factors. Despite this understanding, the clinical epidemiological status of psoriasis patients with a family history of the disease
Lu Cao, Lu Cao, Lingyi Lu, Lingyi Lu, Yingzhe Yu, Yingzhe Yu, Huiying Zhou, Huiying Zhou, Bingjiang Lin, Bingjiang Lin   +9 more
doaj   +1 more source

Anti-interleukin 4 receptor α antibody for the treatment of Chinese bullous pemphigoid patients with diverse comorbidities and a 1-year follow-up: a monocentric real-world study

Frontiers in Immunology, 2023
BackgroundBullous pemphigoid (BP) is a common subepidermal bullous disorder that lacks adequate treatment alternatives. Dupilumab, an anti-interleukin (IL) 4 receptor α antibody blocking Th2 molecules IL-4 and 13, has been used off-label and shown to be ...
Si-Hang Wang, Ying Shan, Ying Shan, Si-Zhe Li, Ya-Gang Zuo   +4 more
doaj   +1 more source

On the crossroad between tolerance and posttransplant lymphoma. [PDF]

, 1997
The role of the Epstein-Barr virus in the development of post-transplant lymphomas is well established. However, not all lymphomas that arise in these patients contain Epstein-Barr virus, suggesting that other cofactors are involved in tumor pathogenesis.
Nalesnik, Michael A, Starzl, Thomas E
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source