Results 51 to 60 of about 2,376,976 (334)

Stochastic Inheritance of Division and Death Times Determines the Size and Phenotype of CD8+ T Cell Families

Frontiers in Immunology, 2019
After antigen stimulation cognate naïve CD8+ T cells undergo rapid proliferation and ultimately their progeny differentiates into short-lived effectors and longer-lived memory T cells. Although the expansion of individual cells is very heterogeneous, the
Aridaman Pandit, Aridaman Pandit, Aridaman Pandit, Rob J. De Boer   +3 more
doaj   +1 more source

The Bone Marrow as Sanctuary for Plasma Cells and Memory T-Cells: Implications for Adaptive Immunity and Vaccinology

Cells, 2021
The bone marrow (BM) is key to protective immunological memory because it harbors a major fraction of the body’s plasma cells, memory CD4+ and memory CD8+ T-cells. Despite its paramount significance for the human immune system, many aspects of how the BM
Stefan A. Slamanig, Martijn A. Nolte
doaj   +1 more source

Neoantigen vaccines: advancing personalized cancer immunotherapy [PDF]

Exploration of Immunology
Neoantigen vaccines are a promising strategy in cancer immunotherapy that leverage tumor-specific mutations to elicit targeted immune responses. Although they have considerable potential, development challenges related to antigen prediction accuracy ...
Alaa A. A. Aljabali, Yassmen Hamzat, Alaa Alqudah, Lorca Alzoubi   +3 more
doaj   +1 more source

The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination [PDF]

, 2018
Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses.
Gray, Joshua I., Macleod, Megan K.L., Westerhof, Lotus   +2 more
core   +1 more source

Prolonged Impairment of Immunological Memory After Anti-CD20 Treatment in Pediatric Idiopathic Nephrotic Syndrome

Frontiers in Immunology, 2019
Anti-CD20 therapy is effective in idiopathic nephrotic syndrome (INS). However, transient or sustained hypogammaglobulinemia predisposing to an increased risk of infectious diseases can follow treatment in some patients. We analyzed the long-term effects
M. Colucci, R. Carsetti, Jessica Serafinelli, Salvatore Rocca, L. Massella, A. Gargiulo, A. Lo Russo, C. Capponi, N. Cotugno, O. Porzio, A. Onetti Muda, P. Palma, F. Emma, M. Vivarelli   +13 more
semanticscholar   +1 more source

CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

Mediators of Inflammation, 2019
The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and ...
Kang Wu, Fei Wang, Guangwu Guo, Yuqing Li, Li-Jun Qiu, Xuefeng Li   +5 more
doaj   +1 more source

EVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE

Медицинская иммунология, 2014
. A full-scale development of post-vaccinal immunity is determined by T and B cell-dependent immunological memory which is formed in response to vaccine injection. However, a capacity of existing and newly developed vaccines to stimulate T cell-dependent
A. N. Naikhin, D. A. Koren’kov, G. D. Petukhova, T. V. Chirkova, E. P. Grigorieva, L. G. Rudenko   +5 more
doaj   +1 more source

INDUCTION OF LONG-TERM T AND B CELL MEMORY IMMUNITY TO INFLUENZA A VIRUS (H5N1) IN PERSONS VACCINATED WITH LIVE INFLUENZA A VACCINE (H5N2)

Медицинская иммунология, 2017
Over last years, a novel strategy for vaccination of people against potentially pandemic influenza A viruses is actively developed worldwide, i.e., a combined (prime-boost) vaccination.
I. V. Losev, S. A. Donina, G. D. Petukhova, D. A. Korenkov, M. K. Erofeeva, M. A. Stukova, L. G. Rudenko, A. N. Naykhin   +7 more
doaj   +1 more source

Stable Epigenetic Programming of Effector and Central Memory CD4 T Cells Occurs Within 7 Days of Antigen Exposure In Vivo

Frontiers in Immunology, 2021
T cell immunological memory is established within days of an infection, but little is known about the in vivo changes in gene regulatory networks accounting for their ability to respond more efficiently to secondary infections. To decipher the timing and
Sarah L. Bevington, Remi Fiancette, Dominika W. Gajdasik, Peter Keane, Jake K. Soley, Claire M. Willis, Daniel J. L. Coleman, David R. Withers, Peter N. Cockerill   +8 more
doaj   +1 more source

The Role of Serotype-Specific Immunological Memory in Pneumococcal Vaccination: Current Knowledge and Future Prospects

Vaccines, 2019
Streptococcus pneumoniae (S. pneumoniae, pneumococcus) is a major cause of morbidity and mortality worldwide. Achieving long-term immunity against S. pneumoniae through immunization is an important public health priority.
I. Papadatou, Irene Tzovara, P. Licciardi   +2 more
semanticscholar   +1 more source