Results 71 to 80 of about 2,376,976 (334)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

IMMUNOLOGICAL MEMORY IN VITRO [PDF]

The Journal of Experimental Medicine, 1971
The immune responses to sheep erythrocytes of mouse spleen cell suspensions from immune and nonimmune donors were compared in vitro. In vivo immunity was only transiently reflected in vitro, and 8 wk after in vivo immunization the responses of cultures from immunized and nonimmunized mice were virtually identical.
Radcliffe, G N, Axelrad, M A
openaire   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Gastric Subserous Vaccination With Helicobacter pylori Vaccine: An Attempt to Establish Tissue-Resident CD4+ Memory T Cells and Induce Prolonged Protection

Frontiers in Immunology, 2019
Tissue-resident memory T (Trm) cells are enriched at the sites of previous infection and required for enhanced protective immunity. However, the emergence of Trm cells and their roles in providing protection are unclear in the field of Helicobacter ...
Wei Liu, Wei Liu, Zhiqin Zeng, Zhiqin Zeng, Shuanghui Luo, Shuanghui Luo, Chupeng Hu, Chupeng Hu, Ningyin Xu, Ningyin Xu, An Huang, An Huang, Lufeng Zheng, Lufeng Zheng, Eric J. Sundberg, Eric J. Sundberg, Tao Xi, Tao Xi, Yingying Xing, Yingying Xing   +19 more
doaj   +1 more source

Data-Driven Mathematical Model of Apoptosis Regulation in Memory Plasma Cells

Cells, 2022
Memory plasma cells constitutively produce copious amounts of antibodies, imposing a critical risk factor for autoimmune disease. We previously found that plasma cell survival requires secreted factors such as APRIL and direct contact to stromal cells ...
Philipp Burt, Rebecca Cornelis, Gustav Geißler, Stefanie Hahne, Andreas Radbruch, Hyun-Dong Chang, Kevin Thurley   +6 more
doaj   +1 more source

Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

Viruses, 2018
The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses.
J. Albarnaz, Alice A. Torres, Geoffrey L. Smith   +2 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pregnant Women Develop a Specific Immunological Long-Lived Memory Against SARS-COV-2

Frontiers in Immunology, 2022
It is well established that pregnancy induces deep changes in the immune system. This is part of the physiological adaptation of the female organism to the pregnancy and the immunological tolerance toward the fetus. Indeed, over the three trimesters, the
Claudio Fenizia, Claudio Fenizia, Irene Cetin, Irene Cetin, Davide Mileto, Claudia Vanetti, Claudia Vanetti, Irma Saulle, Irma Saulle, Maria Di Giminiani, Marina Saresella, Francesca Parisi, Francesca Parisi, Daria Trabattoni, Mario Clerici, Mario Clerici, Mara Biasin, Valeria Savasi, Valeria Savasi   +18 more
doaj   +1 more source

Immunological Memory in Innate Immunity [PDF]

Journal of Innate Immunity, 2013
‘trained immunity’. Trained immunity provides protection against reinfection in a T-/B-cell-independent manner, with nonspecific potentiation of inflammatory reactions and antimicrobial mechanisms playing a central role in these effects [4] . The current issue of the Journal of Innate Immunity presents a series of studies that shed additional light on ...
Netea, M.G., Netea, M.G.
openaire   +4 more sources