Results 91 to 100 of about 10,181,415 (248)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Table_1_HIV-Sheltering Platelets From Immunological Non-Responders Induce a Dysfunctional Glycolytic CD4+ T-Cell Profile.xlsx

, 2022
Immunological non-responders (InRs) are HIV-infected individuals in whom the administration of combination antiretroviral therapy (cART), although successful in suppressing viral replication, cannot properly reconstitute patient circulating CD4+ T-cell ...
Aiwei Zhu (12075422), Pierre de Truchis (323395), Ségolène Greffe (12075425), Elisabeth Rouveix (308408), Claude Capron (5679248), Morgane Bomsel (81994), Fernando Real (185142), Jaja Zhu (10180913)   +7 more
core   +1 more source

Minutes of the 2nd meeting of the Council of the International Union of Immunological Societies

, 1970
Council minutes from the second meeting of the International Union of Immunological Societies in Merligan ...
International Union of Immunological Societies;
core   +1 more source

How to properly define immunological nonresponse to antiretroviral therapy in people living with HIV? an integrative review

Frontiers in Immunology
In recent decades, significant progress has been made in understanding the mechanisms underlying human immunodeficiency virus (HIV) infection and its treatment. Antiretroviral therapy (ART) has notable improved the life expectancy and quality of life for
Maria Carolina Santos Guedes, Maria Carolina Santos Guedes, Henrique Fernando Lopes-Araujo, Henrique Fernando Lopes-Araujo, Kleyverson Feliciano dos Santos, Esaú Simões, Wlisses Henrique Veloso Carvalho-Silva, Wlisses Henrique Veloso Carvalho-Silva, Rafael Lima Guimarães, Rafael Lima Guimarães   +9 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Trauma Symptom Networks: Treatment Responders vs Non-Responders

, 2023
The current study aims to examine baseline trauma symptom networks in treatment responders and non-responders among patients in an intensive partial hospitalization program. Examining differences in trauma symptom networks across treatment responders and
Alexa Skolnik, Clarissa W. Ong
core   +1 more source

Maraviroc intensification for HIV-1-positive immunological non-responders (INRs) despite virological suppression during HAART [PDF]

Journal of the International AIDS Society, 2010
Purpose 15-30% of HAART-treated HIV-1-positive patients (pts) lack CD4+ increase despite full HIV viremia suppression. The increased risk for INR to progress till AIDS led us to investigate maraviroc (MVC) as a tool to intensify HAART in terms of immunological recovery.
S. Rusconi, P. Vitiello, F. Adorni, E. Colella, E. Focà, A. F. Capetti, P. Meraviglia, C. Abeli, S. Bonora, M. D’Annunzio, A. Di Biagio, A. Di Pietro, L. Butini, G. Orofino, S. Farina, G. d’Ettorre, D. Francisci, A. Soria, A. R. Buonomini, C. Tommasi, M. P. Trotta, M. Capasso, E. Merlini, G.C. Marchetti   +23 more
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Characteristics of responders and non-responders.

, 2017
Characteristics of responders and non-responders.
Sang Joon An (3829756), Sang-Bae Ko (3829765), Kyungmi Oh (3829768), Moon-Ku Han (396939), Byung-Woo Yoon (3829762), Chi Kyung Kim (286848), Tae Jung Kim (3829750), Heejung Mo (2509726), Ki-Woong Nam (3829753), Min Kyoung Kang (3829759), Andrew M. Demchuk (425292)   +10 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source