Results 81 to 90 of about 10,572,916 (223)

lncRNAs differentially expressed between responders and non-responders.

, 2020
lncRNAs differentially expressed between responders and non-responders.
Federica Grillo (5306969), Gabriella Cirmena (822833), Stefano Scabini (5306972), Alberto Ballestrero (212236), Emanuele Romairone (5306963), Roberta Gonella (8407233), Roberto Fiocca (6648563), Ciro Marrone (8407230), Roberto Murialdo (6648551), Lorenzo Ferrando (6648539), Edoardo Isnaldi (6648521), Anna Garuti (212195), Luca Mastracci (5306978), Gabriele Zoppoli (201733)   +13 more
core   +1 more source

Maraviroc intensification for HIV-1-positive immunological non-responders (INRs) despite virological suppression during HAART [PDF]

Journal of the International AIDS Society, 2010
Purpose 15-30% of HAART-treated HIV-1-positive patients (pts) lack CD4+ increase despite full HIV viremia suppression. The increased risk for INR to progress till AIDS led us to investigate maraviroc (MVC) as a tool to intensify HAART in terms of immunological recovery.
S. Rusconi, P. Vitiello, F. Adorni, E. Colella, E. Focà, A. F. Capetti, P. Meraviglia, C. Abeli, S. Bonora, M. D’Annunzio, A. Di Biagio, A. Di Pietro, L. Butini, G. Orofino, S. Farina, G. d’Ettorre, D. Francisci, A. Soria, A. R. Buonomini, C. Tommasi, M. P. Trotta, M. Capasso, E. Merlini, G.C. Marchetti   +23 more
openaire   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Multivariable Cox Proportional Hazard Models for Time to first AIDS-defining event or severe non AIDS-defining event or death.

, 2015
List of abbreviations: AIDS, acquired immunodeficiency syndrome; CI, confidence interval; HAART, highly-active antiretroviral treatment; HBsAg, hepatitis B surface antigen; HCV-Ab, hepatitis C virus antibodies; HIV, human immunodeficiency virus; INR ...
Massimo Di Pietro (237801), Franco Maggiolo (372561), Liliane Chatenoud (746686), Francesco Castelli (746687), Giuseppe Lapadula (554894), Andrea Gori (62770), Angelo Pan (554895), Simona Di Giambenedetto (238433), Emanuele Focà (485005), Nicoletta Ladisa (237795), Laura Sighinolfi (237791), Carlo Torti (237805), Massimiliano Fabbiani (239073)   +12 more
core   +1 more source

DataSheet_1_Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders.pdf

, 2021
Immunological non-responders (INR), a subgroup of people living with HIV (PLHIV) who fail to restore CD4+ T cell numbers upon effective antiretroviral treatment, have impaired gut mucosal barrier function and an inferior clinical prognosis compared with ...
Asle Wilhelm Medhus (11532184), Marius Lund-Iversen (8621379), Dag Henrik Reikvam (11532187), Kjetil Taskén (3993311), Charlotte Handeland (11532181), Malin Holm Meyer-Myklestad (11532175), Birgitte Stiksrud (6006068), Dag Kvale (433768), Kristina Berg Lorvik (11532172), Kushi Kushekar (11532178), Anne Margarita Dyrhol-Riise (9075204)   +10 more
core   +1 more source

Comparison of the inflammatory parameters leukocytes and CRP in the groups of responders and non-responders.

, 2018
CRP levels and leukocytes as parameters of inflammation were compared between the groups of responders and non-responders. (A) CRP levels were higher in the group of non-responders (responders: 0.4mg/dl [0.4, 0.5], n = 11, vs. non-responders: 1.6mg/dl [0.
Maria Eveslage (3455072), Christina Wittkamp (5614013), Andrea U. Steinbicker (2873270), Lisa Traeger (2873267), Ines Ellermann (5614016)   +4 more
core   +1 more source

Patient characteristics for the research population; Responders and non-responders.

, 2020
Patient characteristics for the research population; Responders and non-responders.
Mariska A. C. de Jongh (6095867), Leonie de Munter (6095858), Ewout W. Steyerberg (7653068), Suzanne Polinder (360134), Juanita A. Haagsma (8201781), A. J. L. M. Geraerds (8201778), Marjolein van der Vlegel (8622906)   +6 more
core   +1 more source

Qualitative Immune Modulation by Interleukin-2 (IL-2) Adjuvant Therapy in Immunological Non Responder HIV-Infected Patients

PLoS ONE, 2010
Treatment of HIV-infected patients with interleukin-2 (IL-2) produces significant increases in CD4 T cell counts; however an associated qualitative improvement in cells function has yet to be conclusively demonstrated. By measuring mycobacterial killing activity, we evaluated IL-2-mediated functional immune enhancement ex vivo in immunological non ...
Francesca Sabbatini, Alessandra Bandera, Alessandra Bandera, Giulio Ferrario, Daria Trabattoni, Giulia Marchetti, Fabio Franzetti, Mario Clerici, Andrea Gori   +8 more
openaire   +4 more sources