Results 81 to 90 of about 10,181,415 (248)

Functional status following pulmonary rehabilitation: responders and non-responders [PDF]

, 2022
The 6 min walking test (6MWT) has been largely studied. Less is, however, known about responders and non-responders to pulmonary rehabilitation (PR) in other meaningful activities.
Andrade, Lília, Spruit, M.A., Lília Andrade, Souto-Miranda, S., Alda Marques, Martijn A. Spruit, Marques, A., Cravo, João, Mendes, M.A., Sara Souto-Miranda, Marques, Alda, Spruit, Martijn A., Mendes, Maria A., João Cravo, Souto-Miranda, Sara, Cravo, J., Andrade, L., Maria A. Mendes   +17 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Impact of long-term viral suppression in CD4+ recovery of HIV-children on Highly Active Antiretroviral Therapy

BMC Infectious Diseases, 2006
Background The effects of HAART may differ between children and adults because children have a developing immune system, and the long-term immunological outcome in HIV-infected children on HAART is not well-known.
Gurbindo-Gutierrez Dolores, Ramos Jose T, Martin-Fontelos Pablo, Bellon José M, Leon Juan A, Resino Rosa, Resino Salvador, de Jose Maria I, Ciria Luis, Muñoz-Fernandez Maria A   +9 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Responders and non-responders characteristics.

, 2019
Responders and non-responders characteristics.
Nick Sevdalis (221168), Mariana F. Almas (7114577), Xiaoyan Lu (226200), Coralie Lecomte (7114574), Hélène Bricout (2658079), Laurence Torcel-Pagnon (7114571), Ian Matthews (2495419), Ana Wheelock (289081)   +7 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Response assessment of GBM during immunotherapy by delayed contrast treatment response assessment maps

Frontiers in Neurology
IntroductionAssessing the treatment response of glioblastoma multiforme during immunotherapy (IT) is an open issue. Treatment response assessment maps (TRAMs) might help distinguish true tumor progression (TTP) and pseudoprogression (PsP) in this setting.
Valeria Cuccarini, Filippo Savoldi, Yael Mardor, Yael Mardor, David Last, Serena Pellegatta, Federica Mazzi, Maria Grazia Bruzzone, Elena Anghileri, Bianca Pollo, Luisa Maddaloni, Camilla Russo, Elisa Bocchi, Valentina Pinzi, Marica Eoli, Domenico Aquino   +15 more
doaj   +1 more source

Stimulation of PBMC and Monocyte-derived-Macrophages via Toll-Like Receptor (TLRs) Activates Innate Immune Pathways in HIV-Infected Patients on Virally-Suppressive Combination Antiretroviral Therapy (cART)

Frontiers in Immunology, 2016
In HIV-infected cART-treated patients, immune activation and microbial translocation persist and associate with inadequate CD4 recovery and morbidity/mortality.
Esther Merlini, Camilla Tincati, Mara Biasin, Irma Saulle, Federico Angelo Cazzaniga, Antonella d'Arminio Monforte, Amedeo J Cappione, Jennifer Snyder-Cappione, Mario (Mago) Clerici, Mario (Mago) Clerici, Giulia Carla Marchetti   +10 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Characteristics of Immunological Non-Responders in People Living with HIV at Abepura Hospital Papua

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
Infection of Human Immunodeficiency Virus (HIV) lowers the body's immune system, especially CD4+ cells, making it more susceptible to opportunistic infections. Approximately 10-40% of People Living with HIV/AIDS (PLHIV) fail to achieve normal levels of CD4+ T cells despite continued virological suppression, a condition called Immunological Non ...
Justina Berry Sembiring, Agnes Rengga Indrati, Widya Amalia   +2 more
openaire   +1 more source