Results 71 to 80 of about 10,181,415 (248)

An Immunological Non-responder Human Immunodeficiency Virus/Hepatitis C Virus Coinfected Patient: Considerations About a Clinical Case

Cureus, 2023
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections are two chronic viral infections that share the same mode of transmission, making HIV/HCV coinfection frequent. Highly active antiretroviral therapy (HAART) was a turning point in HIV treatment and has been shown to successfully restore immune function and reduce the frequency of
Soares Correia, Rui, França, Margarida
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Activation and gut-homing of peripheral T cells in HIV immunologic non-responders despite long term viral suppression

PLOS ONE, 2021
ObjectiveSerious non-AIDS disease events (SNAE) are experienced disproportionately by immunologic non-responders (INRs), HIV-infected individuals who do not restore CD4 T cells in blood despite effective viral suppression. We aimed to characterize the inflammatory biomarker profile of the INR phenotype.MethodsBlinded cross-sectional cohort study ...
Rodney K. Rousseau, Leah Szadkowski, Colin M. Kovacs, Michael F. Saikali, Rabea Nadeem, Fat Malazogu, Sanja Huibner, Carolyn L. Cummins, Rupert Kaul, Sharon L. Walmsley   +9 more
openaire   +4 more sources

Add-on Pyridostigmine Enhances CD4⁺ T-Cell Recovery in HIV-1-Infected Immunological Non-Responders: A Proof-of-Concept Study. [PDF]

Front Immunol, 2017
In human immunodeficiency virus (HIV)-infection, persistent T-cell activation leads to rapid turnover and increased cell death, leading to immune exhaustion and increased susceptibility to opportunistic infections. Stimulation of the vagus nerve increases acetylcholine (ACh) release and modulates inflammation in chronic inflammatory conditions, a ...
Valdés-Ferrer SI, Crispín JC, Belaunzarán-Zamudio PF, Rodríguez-Osorio CA, Cacho-Díaz B, Alcocer-Varela J, Cantú-Brito C, Sierra-Madero J.   +7 more
europepmc   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Nature Communications, 2022
Seasonal influenza vaccination is an important strategy to prevent serious disease in the elderly, but individual responsiveness to vaccination widely vary.
Peggy Riese, Stephanie Trittel, Manas K. Akmatov, Marcus May, Jana Prokein, Thomas Illig, Christoph Schindler, Birgit Sawitzki, Yassin Elfaki, Stefan Floess, Jochen Huehn, Adrian J. Błażejewski, Till Strowig, Esteban A. Hernandez-Vargas, Robert Geffers, Bowen Zhang, Yang Li, Frank Pessler, Carlos A. Guzmán   +18 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Responders vs. non-responders.

, 2016
Responders vs. non-responders.
Leonid Goubergrits (147403), Eckart Fleck (114516), Sebastian Kelle (114520), Titus Kuehne (2579659), Adelina Doltra (2579656), Arthur Hartmann (2579662), Murray Esler (491549), Ernst Wellnhofer (442512), Christopher Schneeweis (114493), Bernhard Schnackenburg (114494), Philipp Stawowy (442513), Rolf Gebker (114506)   +11 more
core   +1 more source

Early Pro-Inflammatory Signal and T-Cell Activation Associate With Vaccine-Induced Anti-Vaccinia Protective Neutralizing Antibodies

Frontiers in Immunology, 2021
Both vaccine “take” and neutralizing antibody (nAb) titer are historical correlates for vaccine-induced protection from smallpox. We analyzed a subset of samples from a phase 2a trial of three DNA/HIV-1 primes and a recombinant Tiantan vaccinia virus ...
Jue Hou, Shuhui Wang, Dan Li, Lindsay N. Carpp, Tong Zhang, Ying Liu, Manxue Jia, Hong Peng, Chang Liu, Hao Wu, Yunda Huang, Yiming Shao   +11 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source