Results 51 to 60 of about 10,572,916 (223)

Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression data [PDF]

, 2012
Background: For several immune-mediated diseases, immunological analysis will become more complex in the future with datasets in which cytokine and gene expression data play a major role. These data have certain characteristics that require sophisticated
Lluis Anna, Ballenberger, Nikolaus, Nikolaus Ballenberger, Schaub, Bianca, Mutius, Erika von, Illi, Sabina, Sabina Illi (125183), Bianca Schaub (125191), Illi Sabina, Nikolaus Ballenberger (125172), von Mutius Erika, Lluis, Anna, Bianca Schaub, Erika von Mutius, Anna Lluis, Ballenberger Nikolaus, Sabina Illi, Anna Lluis (125177), Erika von Mutius (105805), Schaub Bianca   +19 more
core   +2 more sources

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Multivariable Cox Proportional Hazard Models for Time to severe non-AIDS related event.

, 2015
List of abbreviations: AIDS, acquired immunodeficiency syndrome; CI, confidence interval; HAART, highly-active antiretroviral treatment; HBsAg, hepatitis B surface antigen; HCV-Ab, hepatitis C virus antibodies; HIV, human immunodeficiency virus; INR ...
Massimo Di Pietro (237801), Franco Maggiolo (372561), Liliane Chatenoud (746686), Francesco Castelli (746687), Giuseppe Lapadula (554894), Andrea Gori (62770), Angelo Pan (554895), Simona Di Giambenedetto (238433), Emanuele Focà (485005), Nicoletta Ladisa (237795), Laura Sighinolfi (237791), Carlo Torti (237805), Massimiliano Fabbiani (239073)   +12 more
core   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

An Immunological Non-responder Human Immunodeficiency Virus/Hepatitis C Virus Coinfected Patient: Considerations About a Clinical Case

Cureus, 2023
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections are two chronic viral infections that share the same mode of transmission, making HIV/HCV coinfection frequent. Highly active antiretroviral therapy (HAART) was a turning point in HIV treatment and has been shown to successfully restore immune function and reduce the frequency of
Soares Correia, Rui, França, Margarida
openaire   +2 more sources

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Responders and non-responders characteristics.

, 2019
Responders and non-responders characteristics.
Nick Sevdalis (221168), Mariana F. Almas (7114577), Xiaoyan Lu (226200), Coralie Lecomte (7114574), Hélène Bricout (2658079), Laurence Torcel-Pagnon (7114571), Ian Matthews (2495419), Ana Wheelock (289081)   +7 more
core   +1 more source

Activation and gut-homing of peripheral T cells in HIV immunologic non-responders despite long term viral suppression

PLOS ONE, 2021
ObjectiveSerious non-AIDS disease events (SNAE) are experienced disproportionately by immunologic non-responders (INRs), HIV-infected individuals who do not restore CD4 T cells in blood despite effective viral suppression. We aimed to characterize the inflammatory biomarker profile of the INR phenotype.MethodsBlinded cross-sectional cohort study ...
Rodney K. Rousseau, Leah Szadkowski, Colin M. Kovacs, Michael F. Saikali, Rabea Nadeem, Fat Malazogu, Sanja Huibner, Carolyn L. Cummins, Rupert Kaul, Sharon L. Walmsley   +9 more
openaire   +4 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Add-on Pyridostigmine Enhances CD4⁺ T-Cell Recovery in HIV-1-Infected Immunological Non-Responders: A Proof-of-Concept Study. [PDF]

Front Immunol, 2017
In human immunodeficiency virus (HIV)-infection, persistent T-cell activation leads to rapid turnover and increased cell death, leading to immune exhaustion and increased susceptibility to opportunistic infections. Stimulation of the vagus nerve increases acetylcholine (ACh) release and modulates inflammation in chronic inflammatory conditions, a ...
Valdés-Ferrer SI, Crispín JC, Belaunzarán-Zamudio PF, Rodríguez-Osorio CA, Cacho-Díaz B, Alcocer-Varela J, Cantú-Brito C, Sierra-Madero J.   +7 more
europepmc   +5 more sources