Results 51 to 60 of about 9,541 (146)

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Genetic inactivation of the phosphatase activity of soluble epoxide hydrolase prevents the development of pulmonary hypertension in rats, partly through upregulation of SIRT3 expression and decreased cell proliferation and apoptosis‐related proteins. Targeting sEH‐P emerges as a promising therapeutic strategy for pulmonary hypertension.
Matthieu Leuillier, Mustapha Chelgham, Hind Messaoudi, Ly Tu, Severine Ménoret, Raphaël Thuillet, Déborah Groussard, Felix F. Lillich, Mina Ottaviani, Lionel Nicol, Paul Mulder, Marc Humbert, Vincent Richard, Ignacio Anegon, Christophe Morisseau, Ewgenij Proschak, Christophe Guignabert, Jérémy Bellien   +17 more
wiley   +1 more source

Motivation as an important criterion for graduation among medical students admitted from the waiting list

GMS Journal for Medical Education, 2019
Aim: Graduation rates among medical students who have been admitted to medical school from the waiting list quota are significantly lower than those for medical students who are directly admitted on the basis of their competitive secondary school ...
Herbst, Carolin Verena, Müller-Hilke, Brigitte   +1 more
doaj   +1 more source

Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross‐Presentation

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross‐presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated.
Alice Senni, Louise Grumbach, Sara Ceccacci, Mathieu Frechin, Nicolas Goudin, Ida Chiara Guerrera, Barbara Bertocci, Peter van Endert   +7 more
wiley   +1 more source

FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection

Frontiers in Immunology, 2017
Tripartite motif (TRIM) proteins are involved in various cellular functions and constitute key factors of the antiviral innate immune response.
Christelle Langevin, Elina Aleksejeva, Armel Houel, Valérie Briolat, Valérie Briolat, Corinne Torhy, Aurélie Lunazzi, Jean-Pierre Levraud, Jean-Pierre Levraud, Pierre Boudinot   +9 more
doaj   +1 more source

Fat‐Corrected Non‐Gaussian Diffusion MRI for Liver Fibrosis Assessment in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 497-507, February 2026.
ABSTRACT Background In patients with metabolic dysfunction‐associated steatotic liver disease (MASLD), non‐Gaussian diffusion—weighted imaging (DWI) has been proposed for the diagnosis of liver fibrosis, but its measurement is partially confounded by steatosis.
Omaïma Saïd, Sabrina Doblas, Valérie Paradis, Pierre Bedossa, Dominique Valla, Cédric Laouénan, Laurent Castera, Bernard E. Van Beers, Philippe Garteiser   +8 more
wiley   +1 more source

Children and Adolescents With Localised Non‐Rhabdomyosarcoma Soft Tissue Sarcoma: Results of the CWS‐96 and CWS‐2002P Prospective Trials With Reclassification of the Trial Data Incorporating the Recent Soft Tissue Sarcoma Registry

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background Here we report the results of the first comprehensive European trials for all soft tissue sarcoma entities, which aimed to develop a new risk stratification system, limit radiotherapy and chemotherapy for low‐/standard‐risk patients, and evaluate different chemotherapy regimens for high‐risk patients.
Amadeus T. Heinz, Anton Schönstein, Ewa Koscielniak, Martin Ebinger, Jörg Fuchs, Semi Harrabi, Christian Vokuhl, Roland Imle, Sabine Stegmaier, Ines B. Brecht, Gustaf Ljungman, Hanna Juntti, Ruth Ladenstein, Bernarda Kazanowska, Thomas Klingebiel, Kristian W. Pajtler, Monika Sparber‐Sauer   +16 more
wiley   +1 more source

Highly Infectious Prions Generated by a Single Round of Microplate-Based Protein Misfolding Cyclic Amplification

mBio, 2014
Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuable, sensitive tool, it is currently hampered by its lack of ...
Mohammed Moudjou, Pierre Sibille, Guillaume Fichet, Fabienne Reine, Jérôme Chapuis, Laetitia Herzog, Emilie Jaumain, Florent Laferrière, Charles-Adrien Richard, Hubert Laude, Olivier Andréoletti, Human Rezaei, Vincent Béringue   +12 more
doaj   +1 more source

Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase

Clinical and Developmental Immunology, 2012
Pancreatic ductal adenocarcinoma (PDAC) is frequently associated with fibrosis and a prominent inflammatory infiltrate in the desmoplastic stroma. Moreover, in PDAC, an epithelial-to-mesenchymal transition (EMT) is observed.
Thomas Große-Steffen, Thomas Giese, Nathalia Giese, Thomas Longerich, Peter Schirmacher, G. Maria Hänsch, Matthias M. Gaida   +6 more
doaj   +1 more source

The carRS-ompV-virK operon of Vibrio cholerae senses antimicrobial peptides and activates the expression of multiple resistance systems

Scientific Reports
Antimicrobial peptides are small cationic molecules produced by eukaryotic cells to combat infection, as well as by bacteria for niche competition. Polymyxin B (PmB), a cyclic antimicrobial peptide, is used prophylactically in livestock and as a last ...
Annabelle Mathieu-Denoncourt, Gregory B Whitfield, Antony T Vincent, Cécile Berne, Julien Pauzé-Foixet, Feriel C Mahieddine, Yves V Brun, Marylise Duperthuy   +7 more
doaj   +1 more source

Characterization and effective expansion of CD4−CD8− TCRαβ+ T cells from individuals living with type 1 diabetes

Molecular Therapy: Methods & Clinical Development
CD4−CD8− TCRαβ+ (double-negative [DN]) T cells represent a rare T cell population that promotes immunological tolerance through various cytotoxic mechanisms.
J. Ernesto Fajardo-Despaigne, Félix Lombard-Vadnais, Adam-Nicolas Pelletier, Aïnhoa Olazabal, Lucie Boutin, Sarah Pasquin, Valérie Janelle, Laurent Legault, Jean-Sébastien Delisle, Erin E. Hillhouse, Lise Coderre, Sylvie Lesage   +11 more
doaj   +1 more source