Results 61 to 70 of about 9,541 (146)

Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis

Cell Communication and Signaling, 2018
Background Notch signaling controls many cellular processes, including cell fate determination, cell differentiation, proliferation and apoptosis. In mammals, four Notch receptors (Notch 1–4) can interact with five distinct ligands [Jagged1, Jagged2 ...
Sylvain Pagie, Nathalie Gérard, Béatrice Charreau   +2 more
doaj   +1 more source

Approche immunochimique de la structure de la protéine cellulaire PrPc ovine. Caractérisation d’anticorps discriminant les glycoformes et les allèles de la protéine Prion chez le mouton

INRAE Productions Animales, 2004
Les Encéphalopathies Spongiformes Transmissibles (EST) sont des maladies neurodégénératives caractérisées par l’accumulation dans le cerveau d’une forme anormale de la protéine prion, la PrP.
M. MOUDJOU, E. SABUNCU, D. VILETTE, A. LEDUR, H. LAUDE   +4 more
doaj   +1 more source

Divergent prion strain evolution driven by PrPC expression level in transgenic mice

Nature Communications, 2017
PrPC protein plays a key role in prion transmission across species. Here, the authors compare transmission of a representative scrapie isolate to transgenic mice expressing variable levels of the same Prnp allele as the donor sheep, and find divergent ...
Annick Le Dur, Thanh Lan Laï, Marie-George Stinnakre, Aude Laisné, Nathalie Chenais, Sabine Rakotobe, Bruno Passet, Fabienne Reine, Solange Soulier, Laetitia Herzog, Gaëlle Tilly, Human Rézaei, Vincent Béringue, Jean-Luc Vilotte, Hubert Laude   +14 more
doaj   +1 more source

The HmrABCX pathway regulates the transition between motile and sessile lifestyles in Caulobacter crescentus by a mechanism independent of hfiA transcription

mBio
During its cell cycle, the bacterium Caulobacter crescentus switches from a motile, free-living state, to a sessile surface-attached cell. During this coordinated process, cells undergo irreversible morphological changes, such as shedding of their polar ...
Sébastien Zappa, Cécile Berne, Robert I. Morton III, Gregory B. Whitfield, Jonathan De Stercke, Yves V. Brun   +5 more
doaj   +1 more source

Combination of t(4;14), del(17p13), del(1p32) and 1q21 gain FISH probes identifies clonal heterogeneity and enhances the detection of adverse cytogenetic profiles in 233 newly diagnosed multiple myeloma

Molecular Cytogenetics, 2017
Background Our aim was to set the FISH combination of del(17p13), t(4;14), 1q21 gain and del(1p32), four adverse cytogenetic factors rarely evaluated together, and compare our technical thresholds with those defined in the literature. Methods Two hundred
Thomas Smol, Annika Dufour, Sabine Tricot, Mathieu Wemeau, Laure Stalnikiewicz, Franck Bernardi, Christine Terré, Benoît Ducourneau, Hervé Bisiau, Agnès Daudignon   +9 more
doaj   +1 more source

P589: AGE AND AGE-ADAPTED RISK FACTORS HIGHLY INFLUENCE SURVIVAL PROBABILITY IN AML PATIENTS – A RETROSPECTIVE ANALYSIS

HemaSphere, 2022
K. Nachtkamp, C. Zahner, A. Fricke, T. Ulrych, F. I. Schulz, A. Kündgen, P. S. Jäger, G. Kobbe, U. Germing   +8 more
doaj   +1 more source

Phenotypic plasticity in cell elongation among closely related bacterial species

Nature Communications
Cell elongation in bacteria has been studied over many decades, in part because its underlying mechanisms are targets of numerous antibiotics. While multiple elongation modes have been described, little is known about how these strategies vary across ...
Marie Delaby, Liu Yang, Maxime Jacq, Kelley A. Gallagher, David T. Kysela, Velocity Hughes, Francisco Pulido, Frederic J. Veyrier, Michael S. VanNieuwenhze, Yves V. Brun   +9 more
doaj   +1 more source

Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells

eLife
Precision gene editing in primary hematopoietic stem and progenitor cells (HSPCs) would facilitate both curative treatments for monogenic disorders as well as disease modelling.
Fanny-Mei Cloarec-Ung, Jamie Beaulieu, Arunan Suthananthan, Bernhard Lehnertz, Guy Sauvageau, Hilary M Sheppard, David JHF Knapp   +6 more
doaj   +1 more source

Retraction Note: Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice. [PDF]

Mol Med
Chiazza F, Couturier-Maillard A, Benetti E, Mastrocola R, Nigro D, Cutrin JC, Serpe L, Aragno M, Fantozzi R, Ryffel B, Thiemermann C, Collino M.   +11 more
europepmc   +1 more source

The EcoHD score: a quality improvement tool for the auto-evaluation of the environmental sustainability process in hemodialysis centers. [PDF]

Clin Kidney J
Lasseur C, Ethier I, Rey J, Foucault C, Vérité T, Hourmant M.   +5 more
europepmc   +1 more source