Results 41 to 50 of about 1,328,564 (298)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome [PDF]

, 2016
Several mechanisms exist to avoid or suppress inflammatory T-cell immune responses that could prove harmful to the host due to targeting self-antigens or commensal microbes.
Bancroft, Tara, Bresciani, Anne Gøther, Dillon, Myles B., Greenbaum, Jason, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Schommer, Nina, Sette, Alessandro   +8 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Immunology [PDF]

Journal of Clinical Pathology, 2005
Ian R, Sanderson, W Allan, Walker
openaire   +4 more sources

Mathematical models for immunology:current state of the art and future research directions [PDF]

, 2016
The advances in genetics and biochemistry that have taken place over the last 10 years led to significant advances in experimental and clinical immunology.
A Bauer, A Bellouquid, A Bellouquid, A Carbo, A Chakraborty, A Chakraborty, A Chavali, A Ghaffari, A Hamdache, A Malkin, A Mander, A Moskalensky, A Nag, A Perelson, A Pigozzo, A Prasad, A Smith, A Smith, A Tóth, B Chen, B Cumming, B Goldstein, B Hancioglu, B Kholodenko, B Kidd, B Rivière, B Rouse, B Su, B Thorne, B Zolnik, C Beauchemin, C Bianca, C Bianca, C Bianca, C Bianca, C Davis, C Dool van den, C Gerlach, C Macnamara, C Pommerenke, C Sinclair, D Bandura, D Barua, D Chen, D Choo, D Coombs, D Finlay, D Kirschner, D Laydon, D Liu, D Mallet, D Mathis, D Smith, D Winter, D Wylie, Doreen A. Cantrell, E Ahrens, E Castillo-Montiel, E Hawkins, E Mochan, E Newell, E Numfor, E Pearce, E Pearce, E Rykiel, E Stirk, F Castiglione, F Castiglione, F Crauste, F Fellizi, F Gross, F Pappalardo, F Pappalardo, G An, G Bogle, G Bogle, G Bonizzi, G Huynh, G Lythe, H Caswell, H Knútsdóttir, H Lee, H Miao, H Miao, H Zheng, I Bains, I Baltcheva, I Nahum-Shani, ID Braber, J Beltman, J Currie, J Day, J Dunster, J Faeder, J Flegg, J Flegg, J Gillard, J Heffernan, J Kim, J Köbig, J Linderman, J Mansfield, J Mattes, J Perley, J Reynolds, J Sekar, J Tan, J Wares, Joseph J. Gillard, K Blyuss, K Fujarewicz, K Ganeshan, K García-Martínez, K Janes, K Murphy, K Norris, K Popper, K Saeki, K Smith, K Yoshida, KH Farh, L Balagopalan, L Bayón, L Borghesi, L Canini, L Canini, L DePillis, L Pillis de, L Romani, M Artyomov, M Chaplain, M Fallahi-Sichani, M Figge, M Halling-Brown, M Itik, M Kalos, M Kolev, M Kolev, M Krummel, M Lever, M Mentis, M Nishikori, M Onsum, M Pogson, M Reed, M Sneddon, N Bellomo, N Bellomo, N Burroughs, N Burroughs, N Burroughs, N Cilfone, N Clifone, N Figueroa-Morales, N Kim, N Kronik, N Oreskes, N Strbo, O Dushek, O Serichantalergs, P Ankomah, P Cao, P Francois, P Gannon, P Johnson, P Kim, P Kim, P Kourilsky, P Morel, P Thagard, P Verdijk, Q Yang, R Andersen, R Antia, R Callard, R Callard, R Cheong, R Cheong, R Eftimie, R Eftimie, R Garnier, R Germain, R Germain, R Leander, R Maizels, R Malka, R Medzhitov, R Saenz, R Spreafico, R Stengel, R Williams, R Zinkernagel, Raluca Eftimie, RD Boer, S Adra, S Andrew, S Basak, S Celli, S Dai, S Gadhamsetty, S Gordon, S Henrickson, S Hoops, S Hugues, S Krishna, S Lawley, S Marino, S Marino, S Meraviglia, S Nagaraja, S Otto, S Prokopiou, S Qi, S Tay, S Villar, S Webb, T Lipniacki, T Sun, T Sun, T Tian, TH Lee, U Foryś, U Ledzewicz, U Schnell, V Ganusov, V Kocabas, W Shou, W Singer, Y Chew, Y Kim, Y Kim, Y Louzoun, Y Vodovotz, Y Vodovotz, Y Wang, YF Qi, Z Feng, Z Feng, Z Kabala, Z Shi, Z Yilmaz   +240 more
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Cyclic AMP pathway activation and extracellular zinc induce rapid intracellular zinc mobilization in Candida albicans [PDF]

, 2018
LK was supported by Innovation Fund Denmark, DK (4019-00019B). Pcovery ApS received funding from Wellcome Trust, Research Councils, UK (100480/Z/12), Novo Seeds, DK and Boehringer Ingelheim Venture Fund, D.
Anja T. Fuglsang, Anne-Marie L. Winther, Duncan Wilson, Lasse Kjellerup, Lasse Kjellerup   +4 more
core   +3 more sources