Results 151 to 160 of about 96,912 (310)

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Exploring the Vaccine Adjuvant Effect and Mechanism of <i>Epimedium</i> Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations. [PDF]

Vaccines (Basel)
Tang M, Zhao A, Yang Y, Song Z, Wang S, Ye X, Luo H, Zhao L, Pan J, Zou Q, Sun H, Zeng H.   +11 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Immunomodulation in the Treatment of Disseminated Coccidioidomycosis. [PDF]

Clin Infect Dis
Stephens AV, Thauland TJ, Whitehill GD, Garcia-Lloret MI, Butte MJ.   +4 more
europepmc   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

The delivery of molecular hydrogen (H2) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apoptosis.
Hannan Cui, Tengjiao Wang, Gangfeng Li, Hongbo Wei, Peng Li, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che   +9 more
core   +1 more source

Inside‐Outside ROS Therapeutic Strategy Based on Piezoelectric Nano‐Urchin for Drug‐Resistant Bacteria Biofilm Infections

Advanced Science, EarlyView.
The contribution of this study lies not only in enabling effective treatment of drug‐resistant biofilm infections, but also in establishing a transferable therapeutic paradigm: Ultrasound‐triggered mechanical forces synergistically enhance piezoelectric polarization and nanozyme activity, driving functional ROS generation inside and outside biofilms ...
Xinjian Guo, Jin Yang, Mengjie An, Bingjie Lin, Tao Liu, Limin Zhang   +5 more
wiley   +1 more source

Immunomodulatory Nanomaterials: Design Strategies, Mechanisms, Biomedical Applications, and Future Perspectives. [PDF]

Biomedicines
Thalla M, Kapre S, Srivatsa Palakurthi S, Kolimi P, Akkireddy R, Vaskuri GSSJ, Kommineni N, Sharma R, Kim JD, Palakurthi S.   +9 more
europepmc   +1 more source

Natural Immunomodulators [PDF]

Journal of Immunology Research, 2017
D. Ortuño-Sahagún, K. Zänker, A. K. S. Rawat, S. V. Kaveri, P. Hegde   +4 more
openaire   +3 more sources