Spatiotemporal immunomodulation with programmable biomaterials to promote musculoskeletal tissue regeneration. [PDF]
Liang C, Guo J, Qiao W, Lee SJ.
europepmc +1 more source
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma +2 more
wiley +1 more source
Corrigendum to 'Design and <i>in vitro</i> validation of Brome mosaic -virus-like particles for gene delivery and immunomodulation of melanoma' [Mater. Today Bio <b>36</b>, February 2026, 102693, https://doi.org/10.1016/j.mtbio.2025.102693]. [PDF]
Elbadri K +12 more
europepmc +1 more source
Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu +12 more
wiley +1 more source
Nano-Immunomodulators for Directing Macrophage Fate to Enhance Peripheral Nerve Repair: Advances, Challenges, and Translational Perspectives. [PDF]
Shi S, Yu X, Ou X, Wang Q, Hu D.
europepmc +1 more source
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp +12 more
wiley +1 more source
Role and mechanism of mesenchymal stem cells in endometrial receptivity remodeling. [PDF]
Zhao-Di W +7 more
europepmc +1 more source
Porcine kidney xenotransplantation: From primate models to clinical reality
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
Hydrogel-Based Immunomodulation of Tumor Immune Microenvironment in Hepatocellular Carcinoma: Current Strategies and Future Directions. [PDF]
Zhang S, Ding L, Hou T, Lin D, Qu Y.
europepmc +1 more source

