Results 71 to 80 of about 137,143 (306)

Influence of dexamethasone and gamithromycin on the acute phase response in LPS-challenged calves [PDF]

, 2012
Introduction : Lipopolysaccharide (LPS) is a potent inducer of the bovine acute phase response and has been widely used in research to provoke acute inflammation.
Croubels, Siska, De Backer, Patrick, Pardon, Bart, Plessers, Elke, Watteyn, Anneleen, Wyns, Heidi   +5 more
core  

How do nematodes transfer phosphorylcholine to carbohydrates? [PDF]

, 2010
An unusual aspect of the biology of nematodes is the attachment of phosphorylcholine (PC) to carbohydrate. The attachment appears to play an important role in nematode development and, in some parasitic species, in immunomodulation.
Harnett, W., Houston, K.M., Rzepecka, J.
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

CASPASE-3 expression and activity in PBMCs associate with SARS-CoV-2 infection and clinical features

Clinical Immunology Communications
Background: Although vaccines and treatments exist, new SARS-CoV-2 variants continue to emerge. An imbalance between apoptosis and autophagy may contribute to COVID-19 pathogenesis, leading to tissue damage and inflammation. Objective: To investigate the
Vanessa Mylenna Florêncio de Carvalho, Bárbara de Oliveira Silva, Priscilla Stela Santana de Oliveira, Thacianna Barreto da Costa, Michelle Melgarejo da Rosa, Moacyr Jesus Barreto de Melo Rêgo, Michelly Cristiny Pereira, Maira Galdino da Rocha Pitta   +7 more
doaj   +1 more source

Elevated Pentraxin 3 in Obese Adipose Tissue Promotes Adipogenic Differentiation by Activating Neuropeptide Y Signaling

Frontiers in Immunology, 2018
Obesity is accompanied by chronic systemic inflammation characterized by macrophage infiltration of obese tissues, an elevated plasma level of inflammatory substances, and excessive accumulation of lipids.
Min-Kyung Shin, Min-Kyung Shin, Bongkun Choi, Bongkun Choi, Eun-Young Kim, Eun-Young Kim, Ji-Eun Park, Ji-Eun Park, Eui Seung Hwang, Hyang Ju Lee, Hyang Ju Lee, Min Kyung Kim, Min Kyung Kim, Ji-Eun Kim, Seong Who Kim, Seong Who Kim, Eun-Ju Chang, Eun-Ju Chang   +17 more
doaj   +1 more source

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Heat-killed Mycobacterium tuberculosis induces trained immunity in vitro and in vivo administered systemically or intranasally

iScience
Summary: Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be initiated with various compounds such as fungal β-glucan or the tuberculosis vaccine, Bacillus Calmette-Guérin.
Luna Minute, Marta Bergón-Gutiérrez, Pablo Mata-Martínez, Jaime Fernández-Pascual, Verónica Terrón, Laura Bravo-Robles, Gülce Bıçakcıoğlu, Gabriela Zapata-Fernández, Nacho Aguiló, Eduardo López-Collazo, Carlos del Fresno   +10 more
doaj   +1 more source

Coacervates Made of Elastin‐Like Polypeptides Fused with Melanocyte‐Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord‐Injured Mice

Advanced Healthcare Materials, EarlyView.
Pressure skin wounds are frequent complications after spinal cord injury (SCI), with impaired healing due to vascular and immune deficits. Elastin‐like polypeptides (ELP) fused to α‐MSH (MSH‐ELP) or MCP‐1 (MCP‐ELP) are developed and tested on these wounds. The resulting nanoparticles are non‐toxic and bioactive, and they enhance macrophage recruitment,
Suneel Kumar, Dhruv Patel, Greeshma Manjunath, Shashank Madhavan, Ashley Mathew, Dnyaneshwari Rananavare, Jahnavi Shah, Francois Berthiaume   +7 more
wiley   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source