Results 201 to 210 of about 203,110 (265)

A Sprayable Nanoplatform Breaks the Vicious Cycle of Diabetic Wounds via Photoactivated Antioxidant and Drug Delivery

Advanced Science, EarlyView.
A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo, Yuanyuan Meng, Qixiang Gui, Xi‐Tao Yang, Yong Fan, Xiaodong Zhu   +5 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Immunomodulatory activity of Trypanosoma cruzi recombinant antigen combination TSA-1-C4 and Tc24-C4 induce activation of macrophages and CD8⁺ T cells. [PDF]

Parasitol Res
Dzul-Huchim VM, Rosado-Vallado M, Euan-Canto A, Torres-Romero J, Ortega-Lopez J, Cruz-Chan JV, Villanueva-Lizama LE, Arana-Argáez V.   +7 more
europepmc   +1 more source

Pap12-6: A host defense peptide with potent immunomodulatory activity in a chicken hepatic cell culture. [PDF]

PLoS One
Márton RA, Sebők C, Mackei M, Tráj P, Vörösházi J, Kemény Á, Neogrády Z, Mátis G.   +7 more
europepmc   +1 more source

Leishmanicidal and immunomodulatory activity of Terminalia catappa in Leishmania amazonensisin vitro infection. [PDF]

Heliyon
de Araújo SA, Silva CMP, Costa CS, Ferreira CSC, Ribeiro HS, da Silva Lima A, Quintino da Rocha C, Calabrese KDS, Abreu-Silva AL, Almeida-Souza F.   +9 more
europepmc   +1 more source

Effect of modification methods on the physical properties and immunomodulatory activity of particulate β-glucan. [PDF]

Food Sci Biotechnol
Lee HN, Lim HJ, Park JY, Choi JH, Hong SJ, Jang DE, Kim TS, Seong SH, Kim BR, Kim JH, Seo C, Park JH, Jeong JW, Kim YM.   +13 more
europepmc   +1 more source

Human breast milk isolated lactic acid bacteria: antimicrobial and immunomodulatory activity on the <i>Galleria mellonella</i> burn wound model. [PDF]

Front Cell Infect Microbiol
Guarnieri A, Venditti N, Cutuli MA, Brancazio N, Salvatore G, Magnifico I, Pietrangelo L, Falcone M, Vergalito F, Nicolosi D, Scarsella F, Davinelli S, Scapagnini G, Petronio Petronio G, Di Marco R.   +14 more
europepmc   +1 more source

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Immunomodulatory and cytotoxic activities of euphol

Life Sciences, 2021
This study evaluated the effect of euphol isolated from Euphorbia umbellata (Pax) Bruyns latex on the activation of complement pathways (classical (CP), alternative (AP) and lectin (LP)), neutrophil chemotaxis, cytotoxic activity, cell morphology and death in HRT-18 and 3T3 cells lines.CP and AP were assessed using hemolytic assays and ELISA for LP ...
Thais Latansio, de Oliveira, Lorena, Bavia, Pâmela Dias, Fontana, Luiza Stolz, Cruz, Katia Sabrina, Paludo, Amanda Rabello, Crisma, Iara Jose, Messias-Reason, Flávio Luís, Beltrame   +7 more
openaire   +2 more sources