Results 41 to 50 of about 19,820 (199)

Establishment of Humanized EFNB2/B3 Murine Models for Investigating Nipah Virus Pathogenesis

Animal Research and One Health, EarlyView.
ABSTRACT Nipah virus (NiV) is a zoonotic paramyxovirus classified as a WHO priority pathogen, which causes severe respiratory disease and encephalitis in humans with high mortality. Currently, no licensed vaccines or specific antiviral therapies are available.
Wei Dong, Ning Liu, Weining Kong, Xiang Gao, Feifei Guan, Shan Gao, Yuanwu Ma   +6 more
wiley   +1 more source

Imunopatogenesis Penyakit Paru Obstruktif Kronik [Immunopathogenesis Update of COPD]

Jurnal Respirasi, 2018
Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory airway disease and complicated lung tissue. The airways of patients with COPD contain many inflammatory cells including neutrophils, macrophages, CD8 T lymphocytes, CD4 T lymphocytes and ...
Resti Yudhawati, Yuyus Dwi Prasetiyo
doaj   +1 more source

Immunopathogenesis of Autoimmune Hepatitis† [PDF]

Clinical Liver Disease, 2020
http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/15-3-reading-assis a video presentation of this article http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/15-3-interview-assis the interview with the author.
openaire   +2 more sources

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

A triad of gut dysbiosis, dysregulated immunity, and ‘leaky’ gut characterize HCMV associated neonatal cholestasis

Gut Pathogens
Background Gut microbiome dysbiosis and related immune dysfunction have been associated with the pathogenesis of Human Cytomegalovirus (HCMV) infection in infants with neonatal cholestasis (NC) as previously reported by us.
Kalyani Karandikar, Gauri Bhonde, Harsha Palav, Varsha Padwal, Shilpa Velhal, Jacintha Pereira, Himali Meshram, Akshat Goel, Ira Shah, Vainav Patel, Vikrant M. Bhor   +10 more
doaj   +1 more source

Using Gene Expression Analysis to Understand Complex Autoimmune Skin Disease Patients: A Series of Four Canine Cutaneous Lupus Erythematosus Cases

Frontiers in Veterinary Science, 2022
Cutaneous Lupus Erythematosus (CLE) is an autoimmune skin disease that occurs in almost two-thirds of people with Systemic Lupus Erythematosus (SLE) and can exist as its own entity.
Alice A. Amudzi, Cesar Piedra-Mora, Diana Junyue Ma, Neil B. Wong, Clement N. David, Nicholas A. Robinson, Ramón M. Almela, Jillian M. Richmond   +7 more
doaj   +1 more source

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Differential activation of monocytes and PMNs in orofacial granulomatosis patients induced by bacterial and non-bacterial stimuli

Frontiers in Immunology
IntroductionOrofacial Granulomatosis (OFG) is a rare chronic inflammatory disorder characterized by persistent or recurrent swelling of the lips and oral mucosa, often accompanied by granulomatous inflammation in the orofacial region with limited ...
Francesco Palestra, Luca Modestino, Annagioia Ventrici, Arianna Monteforte, Gina Memoli, Anne Lise Ferrara, Leonardo Cristinziano, Remo Poto, Francesca Wanda Rossi, Francesca Wanda Rossi, Francesca Wanda Rossi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Amato De Paulis, Amato De Paulis, Amato De Paulis, Gianni Marone, Gianni Marone, Gianni Marone, Giuseppe Spadaro, Giuseppe Spadaro, Giuseppe Spadaro, Angelica Petraroli, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Maria Rosaria Galdiero, Maria Rosaria Galdiero, Maria Rosaria Galdiero   +30 more
doaj   +1 more source

Innate and Adaptive Immune Response to Pneumonia Virus of Mice in a Resistant and a Susceptible Mouse Strain

Viruses, 2013
Respiratory syncytial virus (RSV) is the leading cause of infant bronchiolitis. The closely related pneumonia virus of mice (PVM) causes a similar immune-mediated disease in mice, which allows an analysis of host factors that lead to severe illness. This
Ellen R. T. Watkiss, Pratima Shrivastava, Natasa Arsic, Susantha Gomis, Sylvia van Drunen Littel-van den Hurk   +4 more
doaj   +1 more source

Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response

Frontiers in Immunology, 2020
Elderly individuals are the most susceptible to an aggressive form of coronavirus disease (COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed among the elderly could explain, at least in part, the age gradient in ...
Lucas Leite Cunha, Sandro Felix Perazzio, Jamil Azzi, Paolo Cravedi, Leonardo Vidal Riella, Leonardo Vidal Riella   +5 more
doaj   +1 more source