Results 31 to 40 of about 19,820 (199)

Immunopathogenesis of alphaviruses

, 2020
Alphaviruses, members of the enveloped, positive-sense, single-stranded RNA Togaviridae family, represent a reemerging public health threat as mosquito vectors expand into new geographic territories. The Old World alphaviruses, which include chikungunya virus, Ross River virus, and Sindbis virus, tend to cause a clinical syndrome characterized by fever,
Victoria K, Baxter, Mark T, Heise
openaire   +3 more sources

The protective and pathogenic roles of IL-17 in viral infections: friend or foe? [PDF]

Open Biology, 2019
Viral infections cause substantial human morbidity and mortality, and are a significant health burden worldwide. Following a viral infection, the host may initiate complex antiviral immune responses to antagonize viral invasion and replication.
Wen-Tao Ma, Xiao-Ting Yao, Qun Peng, De-Kun Chen   +3 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Assessing HIV-1 subtype C infection dynamics, therapeutic responses and reservoir distribution using a humanized mouse model

Frontiers in Immunology
IntroductionWhile HIV-1 subtype C (HIV-1C) is the most prevalent and widely distributed subtype in the HIV pandemic, nearly all current prevention and therapeutic strategies are based on work with the subtype B (HIV-1B).
Snehal Kaginkar, Leila Remling-Mulder, Ashashree Sahoo, Tejaswini Pandey, Pranay Gurav, Jyoti Sutar, Amit Kumar Singh, Ella Barnett, Sivasankar Panickan, Ramesh Akkina, Vainav Patel   +10 more
doaj   +1 more source

Psoriasis: Immunological and genetic blueprints driving pathogenesis and potential for personalized therapies [PDF]

Iranian Journal of Basic Medical Sciences
Psoriasis is a long-lasting inflammatory skin condition that impacts millions globally. The occurrence of this disorder differs significantly across various areas, resulting from a complex interplay of genetic and environmental influences.
Mohamed J. Saadh, Omer Qutaiba B. Allela, Radhwan Abdul Kareem, Gaurav Sanghvi, G. Padma Priya, Rishabh Thakur, Mukesh Kumari, Sofia Gupta, Kakhramon Khaitov, Hayder Naji Sameer, Ahmed Yaseen, Zainab H. Athab, Mohaned Adil   +12 more
doaj   +1 more source

The immunopathogenesis of sarcoidosis

Journal of Autoimmunity
Sarcoidosis is a granulomatous multiorgan disease, thought to result from exposure to yet unidentified antigens in genetically susceptible individuals. The exaggerated inflammatory response that leads to granuloma formation is highly complex and involves the innate and adaptive immune system.
Miedema, Jelle, Cinetto, Francesco, Smed-Sörensen, Anna, Spagnolo, Paolo   +3 more
openaire   +3 more sources

Immunopathogenesis of Behcet's Disease [PDF]

Frontiers in Immunology, 2019
Behcet's disease (BD) is a chronic systemic inflammatory vasculitis of unknown etiology characterized by recurrent episodes of oral aphthous ulcers, genital ulcers, skin lesions, ocular lesions, and other manifestations. Although the pathogenesis of BD is unclear, some studies have shown that immunological aberrations play an important role in the ...
Bainan Tong, Xiaoli Liu, Jun Xiao, Guanfang Su   +3 more
openaire   +3 more sources

Autoantibodies to Extracellular Erythrocyte Band 3 Epitopes Are Associated With Anemia in Plasmodium vivax Infection

American Journal of Hematology, EarlyView.
ABSTRACT Plasmodium vivax‐associated anemia is a multifactorial clinical outcome, in which the destruction of uninfected red blood cells (uRBCs) plays a major role in disease development and severity. Here, we identified autoantibody targets within the extracellular loops of Band 3 (B3), a major erythrocyte transmembrane protein.
Aline Marzano‐Miranda, Vanessa G. Fraga, Cor Jésus F. Fontes, Simone Ladeia‐Andrade, Marcelo U. Ferreira, Daniella C. Bartholomeu, Érika M. Braga   +6 more
wiley   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Age/autoimmunity-associated B cells in inflammatory arthritis: An emerging therapeutic target

Frontiers in Immunology, 2023
Age/autoimmunity-associated B cells (ABCs) are a novel B cell subpopulation with a unique transcriptional signature and cell surface phenotype. They are not sensitive to BCR but rely on TLR7 or TLR9 in the context of T cell-derived cytokines for the ...
Zhen-yu Li, Ming-Long Cai, Yi Qin, Zhu Chen   +3 more
doaj   +1 more source