Results 21 to 30 of about 19,820 (199)

Immunopathogenesis of Eosinophilic Esophagitis [PDF]

Digestive Diseases, 2014
<b><i>Background:</i></b> Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus associated with dysphagia in adults and refractory reflux syndromes in children. <b><i>Methods:</i></b> Immunological and genetic approaches have been used to better understand the pathophysiology ...
Simon H.-U., Straumann A.
openaire   +3 more sources

Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic

Frontiers in Immunology, 2021
BackgroundThe recent emergence of COVID-19, rapid worldwide spread, and incomplete knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited development of therapeutic strategies.
Aliakbar Hasankhani, Abolfazl Bahrami, Abolfazl Bahrami, Negin Sheybani, Behzad Aria, Behzad Hemati, Farhang Fatehi, Hamid Ghaem Maghami Farahani, Ghazaleh Javanmard, Mahsa Rezaee, John P. Kastelic, Herman W. Barkema   +11 more
doaj   +1 more source

Disease Stage-Specific Pathogenicity of CD138 (Syndecan 1)-Expressing T Cells in Systemic Lupus Erythematosus

Frontiers in Immunology, 2020
CD138 (syndecan 1), a member of the heparan-sulfate proteoglycan family, regulates diverse biological responses by interacting with chemokines, cytokines, growth factors, and adhesion molecules.
Lunhua Liu, Kazuyo Takeda, Mustafa Akkoyunlu   +2 more
doaj   +1 more source

Immunopathogenesis of Sarcoidosis

Seminars in Respiratory and Critical Care Medicine
Abstract Sarcoidosis is a granulomatous disease of unknown cause, triggered by an unidentified antigen. Although classically considered a T cell–mediated disorder with an IFN-γ signature driven by Th1, Th17, and Th17.1 cells, its pathogenesis reflects dysregulated crosstalk between innate and adaptive immunity. Granulomas form through
Vagts, Christen, Ascoli, Christian, Jacobson, Jeffrey R.   +2 more
openaire   +2 more sources

Tick-borne neuroinfections: Clinical characteristics, immunopathogenesis, and new pharmacotherapeutic strategies [PDF]

Терапевтический архив, 2016
Aim. To study the semiotics of neurological lesions in patients with tick-borne encephalitis, Ixodes tick-borne borreliosis (ITBB) and mixed infection (MI), their immunopathogenesis, and the possibilities of current pathogenetic pharmacological ...
A B Konkova-reidman
doaj   +1 more source

Protective Immune Signatures Associated with Latent TB Infection in PLHIV—Insights from an Integrative Prospective Immune Monitoring Study

Cells
Understanding how HIV-1 pathogenesis affects systemic and TB specific immunity in the setting of latent (LTBI+) compared to active TB infection could provide actionable insights for the prevention of reactivation.
Shilpa Bhowmick, Pratik Devadiga, Sapna Yadav, Nandan Mohite, Pranay Gurav, Tejaswini Pandey, Varsha Padwal, Namrata Neman, Aarya Suryawanshi, Satyajit Musale, Amit Kumar Singh, Sharad Bhagat, Snehal Kaginkar, Harsha Palav, Shantanu Birje, Shilpa Kerkar, Susan Idicula-Thomas, Vidya Nagar, Priya Patil, Sachee Agrawal, Sushma Gaikwad, Jayanthi Shastri, Nupur Mukherjee, Kiran Munne, Vikrant M. Bhor, Taruna Madan, Vainav Patel   +26 more
doaj   +1 more source

Translational Research Studies Unraveling the Origins of Psoriatic Arthritis: Moving Beyond Skin and Joints

Frontiers in Medicine, 2021
Patients with psoriatic arthritis (PsA) are suffering from a decreased quality of life despite currently available treatments. In the latest years, novel therapies targeting the IL-17/IL-23 and TNF pathways improved clinical outcome.
Janne W. Bolt, Janne W. Bolt, Janne W. Bolt, Chaja M. J. van Ansenwoude, Chaja M. J. van Ansenwoude, Chaja M. J. van Ansenwoude, Ihsan Hammoura, Ihsan Hammoura, Ihsan Hammoura, Marleen G. van de Sande, Marleen G. van de Sande, Marleen G. van de Sande, Lisa G. M. van Baarsen, Lisa G. M. van Baarsen, Lisa G. M. van Baarsen   +14 more
doaj   +1 more source

Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage

eLife
The trimeric SARS-CoV-2 Spike protein mediates viral attachment facilitating cell entry. Most COVID-19 vaccines direct mammalian cells to express the Spike protein or deliver it directly via inoculation to engender a protective immune response.
Chung Park, Il-Young Hwang, Serena Li-Sue Yan, Sinmanus Vimonpatranon, Danlan Wei, Don Van Ryk, Alexandre Girard, Claudia Cicala, James Arthos, John H Kehrl   +9 more
doaj   +1 more source

Exploring the Clinical Features, Immunopathogenesis and Approach to Diagnosis for Generalized Pustular Psoriasis [Podcast]

Clinical, Cosmetic and Investigational Dermatology, 2023
Tina Bhutani,1,* Jason E Hawkes2,* 1Psoriasis and Skin Treatment Center, Department of Dermatology, University of California at San Francisco, San Francisco, CA, USA; 2Department of Dermatology, University of California at Davis, Sacramento, CA ...
Bhutani T, Hawkes JE
doaj  

Ethiology and Immunopathogenesis Peculiarities of Ixodic Tick-Borne Borreliosis

Проблемы особо опасных инфекций, 2009
The characteristics of tick-borne borreliosis agents and borrelia reservoir hosts and vectors are presented in the article. Considered is participation of ticks' saliva components and superficial spirochete antigens in the mechanisms of mammals ...
S. F. Bicketov, V. V. Firstova, I. I. Lyubimov   +2 more
doaj   +1 more source