Results 1 to 10 of about 19,820 (199)

Elite controllers long-term non progressors present improved survival and slower disease progression

Scientific Reports, 2022
Different phenotypes exhibiting no evidences of disease progression have been described in ART-naïve HIV-1 positive individuals. Long-term non progressors (LTNP) and elite controllers (EC) are low frequent examples of immunological and virological ...
Laura Capa, Rubén Ayala-Suárez, Humberto Erick De La Torre Tarazona, Juan González-García, Jorge del Romero, José Alcamí, Francisco Díez-Fuertes   +6 more
doaj   +1 more source

Transcriptomic Evidence of the Immune Response Activation in Individuals With Limb Girdle Muscular Dystrophy Dominant 2 (LGMDD2) Contributes to Resistance to HIV-1 Infection

Frontiers in Cell and Developmental Biology, 2022
LGMDD2 is a rare form of muscular dystrophy characterized by one of the three heterozygous deletions described within the TNPO3 gene that result in the addition of a 15-amino acid tail in the C-terminus.TNPO3 is involved in the nuclear import of splicing
Francisco Diez-Fuertes, Francisco Diez-Fuertes, María Rosa López-Huertas, María Rosa López-Huertas, Javier García-Pérez, Javier García-Pérez, Esther Calonge, Esther Calonge, Mercedes Bermejo, Mercedes Bermejo, Elena Mateos, Elena Mateos, Pilar Martí, Pilar Martí, Nuria Muelas, Nuria Muelas, Juan Jesús Vílchez, Juan Jesús Vílchez, Mayte Coiras, Mayte Coiras, José Alcamí, José Alcamí, José Alcamí, Sara Rodríguez-Mora, Sara Rodríguez-Mora   +24 more
doaj   +1 more source

Immunomodulation—What to Modulate and Why? Potential Immune Targets

Frontiers in Dental Medicine, 2022
Despite over 50 years of research into the immunology of periodontal disease, the precise mechanisms and the role of many cell types remains an enigma. Progress has been limited by the inability to determine disease activity clinically. Understanding the
Su Sheng Quach, Alan Zhu, Ryan S. B. Lee, Gregory J. Seymour   +3 more
doaj   +1 more source

Biological activity of interferons in the novel coronavirus infection COVID-19

Вопросы вирусологии, 2022
Introduction. The immunopathogenesis of the novel coronavirus infection COVID-19 is usually associated with the development of imbalance in the immune response to its causative agent, SARS-CoV-2 virus (Coronaviridae: Coronavirinae: Betacoronavirus ...
T. P. Ospelnikova, D. S. Levitskaya, L. V. Kolodyazhnaya, A. D. Shitova, V. N. Osiptsov, L. R. Arifullina, N. O. Kryukova, D. V. Pakhomov, E. A. Khromova, I. A. Baranova, A. G. Chuchalin, M. P. Kostinov, O. A. Svitich   +12 more
doaj   +1 more source

IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle

Cell Reports, 2016
HIV-1 post-integration latency in CD4+ lymphocytes is responsible for viral persistence despite treatment, but mechanisms involved in the establishment of latent viral reservoirs are not fully understood.
Mayte Coiras, Mercedes Bermejo, Benjamin Descours, Elena Mateos, Javier García-Pérez, María-Rosa López-Huertas, Michael M. Lederman, Monsef Benkirane, José Alcamí   +8 more
doaj   +1 more source

Current understanding of Bacillus anthracis toxin molecules organization and approaches for blocking their cytotoxic action

Инфекция и иммунитет, 2020
Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova, I. G. Shemyakin, I. A. Dyatlov   +2 more
doaj   +1 more source

STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal Dephosphorylation

Frontiers in Immunology, 2019
Signal transducer and activator of transcription (STAT1)1 gain of function (GOF) pathogenic variants have been associated with increased levels of phosphorylated STAT1 and STAT1-dependent cellular responses.
Ofer Zimmerman, Peter Olbrich, Peter Olbrich, Alexandra F. Freeman, Lindsey B. Rosen, Gulbu Uzel, Christa S. Zerbe, Sergio D. Rosenzweig, Hye Sun Kuehn, Kevin L. Holmes, David Stephany, Li Ding, Elizabeth P. Sampaio, Amy P. Hsu, Steven M. Holland   +14 more
doaj   +1 more source

Increased Expression of Tim-3 Is Associated With Depletion of NKT Cells In SARS-CoV-2 Infection

Frontiers in Immunology, 2022
In the ongoing coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), natural killer T (NKT) cells act as primary initiators of immune responses.
Jingzhi Yang, Teding Chang, Liangsheng Tang, Hai Deng, Deng Chen, Jialiu Luo, Han Wu, TingXuan Tang, Cong Zhang, Zhenwen Li, Liming Dong, Xiang-Ping Yang, Zhao-Hui Tang   +12 more
doaj   +1 more source

Promiscuous, Multi-Target Lupane-Type Triterpenoids Inhibits Wild Type and Drug Resistant HIV-1 Replication Through the Interference With Several Targets

Frontiers in Pharmacology, 2018
Current research on antiretroviral therapy is mainly focused in the development of new formulations or combinations of drugs belonging to already known targets. However, HIV-1 infection is not cured by current therapy and thus, new approaches are needed.
Luis M. Bedoya, Luis M. Bedoya, Manuela Beltrán, Javier García-Pérez, Patricia Obregón-Calderón, Oliver Callies, Ignacio A. Jímenez, Isabel L. Bazzocchi, José Alcamí   +8 more
doaj   +1 more source

SARS–CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and Challenges

Infectious Disease Reports, 2021
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel coronavirus that emerged from Wuhan, China in late 2019 causing coronavirus disease-19 (COVID-19).
Andrew R. McGill, Roukiah Khalil, Rinku Dutta, Ryan Green, Mark Howell, Subhra Mohapatra, Shyam S. Mohapatra   +6 more
doaj   +1 more source