Results 41 to 50 of about 59,841 (273)
eLife, 2018 The architecture of normal and diseased tissues strongly influences the development and progression of disease as well as responsiveness and resistance to therapy.
Jia-Ren Lin +7 more
doaj +1 more source
Disease Resolution in Chikungunya—What Decides the Outcome?
Frontiers in Immunology, 2020 Chikungunya disease (CHIKD) is a viral infection caused by an alphavirus, chikungunya virus (CHIKV), and triggers large outbreaks leading to epidemics.
Priyanshu Srivastava +6 more
doaj +1 more source
Immunopathological Mechanisms Underlying Cardiac Damage in Chagas Disease
Pathogens, 2023 In Chagas disease, the mechanisms involved in cardiac damage are an active field of study. The factors underlying the evolution of lesions following infection by Trypanosoma cruzi and, in some cases, the persistence of its antigens and the host response,
Mariana Citlalli De Alba-Alvarado +8 more
doaj +1 more source
The implications of immunopathology for parasite evolution
, 2012 By definition, parasites harm their hosts, but in many infections much of the pathology is driven by the host immune response rather than through direct damage inflicted by parasites.
Boots, Mike +3 more
core +1 more source
Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study
Arthritis Care &Research, EarlyView.Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali +11 more
wiley +1 more source
Advanced Science, EarlyView.[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li +19 more
wiley +1 more source
The overview of Spatial Technologies in the use of Immunopathology
, 2023 SingHealth Immunopathology Workshop; 2023 May 8 ...
Bifulco, C
core +1 more source
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Nature Communications, 2018 Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of ...
Violet R. Mukaro +9 more
doaj +1 more source
Immunopathology of cardiomyopathy in the experimental Chagas disease [PDF]
Memorias do Instituto Oswaldo Cruz, 1999 The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that ...
Milena BP Soares +1 more
doaj +1 more source