Results 61 to 70 of about 59,841 (273)

Deucravacitinib in Active Psoriatic Arthritis: Efficacy and Safety Up to 52 Weeks From the Randomized, Double‐Blind, Phase 3 POETYK PsA‐2 Trial

Arthritis &Rheumatology, EarlyView.
Objective To assess the efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with psoriatic arthritis (PsA) who were naive to biologic disease‐modifying antirheumatic drugs or received tumor necrosis factor inhibitors. Methods In the 52‐week, double‐blind, placebo‐controlled, phase 3 Program for Evaluation
Philip J. Mease, Vinod Chandran, April W. Armstrong, Ricardo Blanco, Alexis Ogdie, Evan L. Siegel, Alice B. Gottlieb, Xiaofeng Zeng, Diamant Thaçi, Mitsumasa Kishimoto, Hendrik Schulze‐Koops, Alan Kivitz, Eva Dokoupilová, Akimichi Morita, Eric M. Ruderman, Michael Plewinski, Kejia Wang, Caroline Sardinas, Eleni Vritzali, John Vaile, Atul Deodhar   +20 more
wiley   +1 more source

The C-type Lectin Receptor-Driven, Th17 Cell-Mediated Severe Pathology in Schistosomiasis: Not All Immune Responses to Helminth Parasites Are Th2 Dominated

Frontiers in Immunology, 2019
Schistosomiasis is a major helminthic disease in which damage to the affected organs is orchestrated by a pathogenic host CD4 T helper (Th) cell-mediated immune response against parasite eggs. In the case of the species Schistosoma mansoni, the resulting
Parisa Kalantari, Stephen C. Bunnell, Miguel J. Stadecker   +2 more
doaj   +1 more source

GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology

, 2022
Code used to perform the analysis for figures 6 and supplementary figure 6 in the manuscript: "GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology" (Immunity ...
Raul Aguirre-Gamboa
core   +1 more source

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

Interleukin-1 regulates follicular T cells during the germinal center reaction

Frontiers in Immunology
IntroductionAntibody production and the generation of memory B cells are regulated by T follicular helper (Tfh) and T follicular regulatory (Tfr) cells in germinal centers.
Aude Belbezier, Paul Engeroff, Gwladys Fourcade, Hélène Vantomme, Romain Vaineau, Bruno Gouritin, Bertrand Bellier, Bertrand Bellier, Isabelle Brocheriou, Nicolas Tchitchek, Stephanie Graff-Dubois, David Klatzmann, David Klatzmann   +12 more
doaj   +1 more source

Immunopathologic Effects of Prednisolone and Cyclosporine A on Feline Immunodeficiency Virus Replication and Persistence

Viruses, 2019
Feline immunodeficiency virus (FIV) induces opportunistic disease in chronically infected cats, and both prednisolone and cyclosporine A (CsA) are clinically used to treat complications such as lymphoma and stomatitis.
Craig Miller, Jordan Powers, Esther Musselman, Ryan Mackie, John Elder, Sue VandeWoude   +5 more
doaj   +1 more source

Immunopathology of Brucella Infection

Recent Patents on Anti-Infective Drug Discovery, 2013
In spite of the protean nature of the disease, inflammation is a hallmark of brucellosis and affected tissues usually exhibit inflammatory infiltrates. As Brucella lacks exotoxins, exoproteases or cytolysins, pathological findings in brucellosis probably arise from inflammation-driven processes.
Baldi, Pablo Cesar, Giambartolomei, Guillermo Hernan   +1 more
openaire   +3 more sources

How can immunopathology shape the evolution of parasite virulence?

, 2011
Immunopathology (immune-mediated pathology) is a ubiquitous cause of disease during infection, but how will parasite exploitation strategies evolve in its presence?
Long, Gráinne H, Boots, Mike, Gráinne H. Long, Mike Boots   +3 more
core   +1 more source

Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis [PDF]

, 2014
Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches.
Sandhu, G, Christopher H. Woelk, Carlton A. W. Evans, Gurjinder Sandhu (161147), Borislav D. Dimitrov (687966), Gurjinder Sandhu, Woelk Christopher H., Liku B. Tezera, Akul Singhania, Thomas, Richard, Agranoff Dan, Sandhu Gurjinder, Liku B. Tezera (405129), Paul T. Elkington, Christopher H. Woelk (195217), Tezera, LB, Friedland Jon S., Jon S Friedland, Sathyamoorthy, Tarangini, Dimitrov, Borislav D., Sathyamoorthy, T, Singhania, A, Elkington, Paul T., Evans Carlton A. W., Agranoff, Dan, Evans, CAW, Richard Thomas, Elkington Paul T., Dimitrov, BD, Borislav D Dimitrov, Friedland, Jon S., Carlton A. W. Evans (687967), Christopher H Woelk, Dan Agranoff, Paul T Elkington, Paul T. Elkington (364501), Tarangini Sathyamoorthy (687964), Agranoff, D, Jon S. Friedland (161158), Tezera, Liku B., Sathyamoorthy Tarangini, Woelk, Christopher H., Borislav D. Dimitrov, Richard Thomas (687965), Akul Singhania (502117), Evans, Carlton A.W., Singhania, Akul, Jon S. Friedland, Tarangini Sathyamoorthy, Liku B Tezera, Sandhu, Gurjinder, Friedland, JS, Carlton A W Evans, Tezera Liku B., Thomas, R, Elkington, PT, Thomas Richard, Woelk, CH, Singhania Akul, Dan Agranoff (377996), Dimitrov Borislav D.   +60 more
core   +1 more source

Immunopathology of Atherosclerosis and Related Diseases: Focus on Molecular Biology

, 2021
In this Special Issue of the International Journal of Molecular Sciences, we include insightful reviews and research papers on the subject “Immunopathology of Atherosclerosis and Related Diseases: Focus on Molecular Biology”.[...
Igor Sobenin, Evgeny Bezsonov, Alexander Orekhov   +2 more
core   +1 more source