Results 81 to 90 of about 59,841 (273)

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Immunopathological characteristics and therapeutic effects of UC-MSCs in a pigeon breeder’s lung mouse model

Acta Biochimica et Biophysica Sinica
Hypersensitivity pneumonitis (HP), including pigeon breeder’s lung (PBL), often progresses from acute inflammation to fibrosis, impairing lung function and limiting targeted therapeutic strategies.
Xu Jingran, Li Li, Zhou Yaping, Abudureheman Zulipikaer, Xue Lexin, Wu Chao, Zou Xiaoguang   +6 more
doaj   +1 more source

Immunopathology of herpes simplex virus-associated neuroinflammation: Unveiling the mysteries.

, 2023
The immunopathology of herpes simplex virus (HSV)-associated neuroinflammation is a captivating and intricate field of study within the scientific community.
Hussain, MS, Khan, R, Dua, K, Kazmi, I, Alzarea, SI, Almalki, WH, Saleem, S, Patel, A, Singh, SK, Altwaijry, N, Patel, S, Samuel, VP, Gupta, G   +12 more
core   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, EarlyView.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Immune checkpoint-engineered virus-like particles induce antigen-specific immune tolerance and protect against food allergy

npj Vaccines
Recent advances in our understanding of immune tolerance, particularly the role of immune checkpoints in peripheral tolerance, have opened promising new avenues for therapeutic interventions in immune-related disorders.
Pierre-Axel Vinot, James Vigneron, Julie Marsande, Béatrice Levacher, Nicolas Tchitchek, David Klatzmann, Bertrand Bellier   +6 more
doaj   +1 more source

Comparative Immunopathology of Toxoplasma gondii Natural Infections in Marmosets (Callithrix spp.) and Howler Monkeys (Alouatta spp.), Brazil. [PDF]

J Med Primatol
ABSTRACT Introduction Neotropical primates (NTPs) present varying susceptibility to toxoplasmosis caused by Toxoplasma gondii, but their immunopathogenic responses remain poorly understood. Materials and Methods Local immune responses were characterized in the liver, spleen, and central nervous system (CNS) of 50 naturally infected NTPs (31 Callithrix ...
Pellegrino M, Santos ALM, Dos Santos Cirqueira C, da Silva Gagliotti GFP, Ewbank AC, Sacristán C, Ressio RA, Fernandes NCCA, Guerra JM, Catão-Dias JL.   +9 more
europepmc   +2 more sources

Microarrayed Allergen Molecules Distinguish IgE Sensitisation to Blomia tropicalis and Dermatophagoides pteronyssinus

Allergy, EarlyView.
This study established a microarray containing a representative panel of purified Blo t and Der p allergens for the identification of patients sensitised to Blo t and/or Der p. Results indicate that the microarray based on Blo t and Der p allergens is a useful tool for the identification of Blo t‐ and/or Der p‐sensitised patients. The microarray may be
Nishelle Dsouza, Siratcha Phanthong, Huey‐Jy Huang, Milena Weber, Eszter Sarzsinszky, Petra Zieglmayer, Gabrielle Pauli, Margarete Focke‐Tejkl, Mikhail Tulaev, Nikolina Todorovic, Walter Keller, Thomas Schlederer, Luis Caraballo, Anchalee Tungtrongchitr, Rudolf Valenta, Pongsakorn Tantilipikorn, Susanne Vrtala   +16 more
wiley   +1 more source

The impact of myeloperoxidase on LCMV-induced immunopathology [PDF]

, 2019
Myeloperoxidase (MPO)-derived ROS constitute an important part of the neutrophil-mediated antimicrobial activity. In bacterial and parasitic infections, MPO has been extensively studied as a major microbicidal molecule against such pathogens. The role of
Paillard, Michelle Arlette
core   +1 more source

Circulating multimeric immune complexes contribute to immunopathology in COVID-19

, 2022
A dysregulated immune response with high levels of SARS-CoV-2 specific IgG antibodies characterizes patients with severe or critical COVID-19. Although a robust IgG response is considered to be protective, excessive triggering of activating Fc-gamma ...
Göppert, Nathalie, Steinmann, Daniel, Voll, Reinhard E., Giese, Sebastian, Huzly, Daniela, Ciminski, Kevin, Grawitz, Andrea Busse, Lother, Achim, Kreutz, Clemens, Salzer, Ulrich, Busse Grawitz, Andrea, Kolb, Philipp, Falcone, Valeria, Bildl, Wolfgang, Morgenthaler, Nils G., Emmerich, Florian, Schwemmle, Martin, Ankerhold, Jakob, Welsink, Tim, Voll, Reinhard, Maul-Pavicic, Andrea, Hengel, Hartmut   +21 more
core   +1 more source

Shared and Distinguishing Features of Late‐Onset Rheumatic Diseases Fulfilling Polymyalgia Rheumatica Classification Criteria

Arthritis &Rheumatology, EarlyView.
Kerem Abacar, Ala Altaie, Andrew Barr, Sarah L. Mackie, Kulveer Mankia, Dennis McGonagle   +5 more
wiley   +1 more source