Results 101 to 110 of about 44,987 (258)

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Immunosenescence phenotypes and prognostic significance of CD8 + CD28− T cells in AIDS-related non-Hodgkin lymphoma

Annals of Medicine
Background AIDS-related non-Hodgkin lymphoma (AR-NHL), a leading malignancy among people living with HIV (PLWH), may not receive standard intensive curative therapies as the general population due to immune deficiency concerns, even in the combined ...
Zixin Kang, Xin Tao, Shuting Wu, Shuai Chu, Jie Peng, Juanjuan Chen   +5 more
doaj   +1 more source

Electron compensation‐gated nanomotor for immunomodulation and microenvironment remodeling in bacterial pneumonia therapy

BMEMat, EarlyView.
A nanomotor featuring an “electronic lock” via electron compensation in an Au‐Ag alloy ensures therapeutic precision. Near‐infrared light acts as a key, unlocking on‐demand Ag+ release for synergistic bactericidal action and microenvironment remodeling to potently treat bacterial pneumonia. Abstract Bacterial pneumonia treatment is severely hampered by
Chenglong Xue, Xiaoyu Zhao, Yuqian Wang, Lijin Shi, Qi Shuai   +4 more
wiley   +1 more source

Mast cell burden and immunophenotype of Chinese patients with cutaneous mastocytosis: a 10-year study with focus on the easily neglected pathogenic features

Frontiers in Medicine
BackgroundCutaneous mastocytosis (CM) is a heterogeneous disease. Challenges remain in the detailed pathological features and pathogenic factors and their potential correlation in Chinese patients.ObjectiveThis study aimed to characterize the ...
Qiannan Jia, Xinran Li, Aiping Fan, Dian Zheng, Shuaixin Li, Weiqi Wang, Siying Li, Jun Li   +7 more
doaj   +1 more source

Features of immunophenotype of pancreatic ductal adenocarcinoma

, 2014
Aim. To determine features of immunophenotype of pancreatic ductal adenocarcinoma. Methods and results. At the immunohistochemical research of biopsy and postoperative material of 120 patients with pancreatic ductal adenocarcinoma the expression ...
A. V. Evseyev
core   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Primary malignant melanoma of the esophagus: two cases with clinicopathological analysis

Shanghai Jiaotong Daxue xuebao. Yixue ban
Primary malignant melanoma of the esophagus (PMME) is an extremely rare malignant tumor. To investigate its clinicopathological characteristics, this study reports the clinicopathological features, immunophenotypes, and prognostic information of two ...
Ge Yuqin, Yu Sitao, Dai Shundong, Ji Tianhai   +3 more
doaj   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Dissecting the mediating role of cytokines in the interaction between immune traits and sepsis: insights from comprehensive mendelian randomization

Frontiers in Immunology
BackgroundSepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection, yet the potential causal relationship between the immunophenotype and sepsis remains unclear.MethodsGenetic variants associated with the ...
Xiangtao Zheng, Yihui Wang, Yuming Wang, Xiaofeng Wang, Lei Pei, Shanzhi Zhao, Fangchen Gong, Ranran Li, Huan Liu, Wenbin Liu, Enqiang Mao, Zhitao Yang, Erzhen Chen, Ying Chen   +13 more
doaj   +1 more source