Results 111 to 120 of about 44,987 (258)

Decision Support Models and Software for the Differential Immunophenotype Diagnostics of Leukosis and Lymphomas

, 2021
This article describes the software and underlined decision support models for the immunophenotype diagnostics of leukosis (leukemia) and lymphomas adjusted for the marker or human leukocyte antigen (CD-antigen) coexpressions.
Belevtsev, Michael, Novoselova, Natalia, Tom, Igor   +2 more
core  

Automated B‐cell and plasma cell identification using unsupervised clustering by FlowSOM and an excel‐based classification model

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Manual gating for plasma cell (PC) identification in multiparametric flow cytometry (MFC) is time‐consuming and operator‐dependent, especially when PCs are scarce. Artificial intelligence approaches such as unsupervised clustering (e.g., FlowSOM) map high‐dimensional data that still require expert interpretation.
Ethan James Gantana, Ernest Musekwa, Erica‐Mari Nell, Zivanai Cuthbert Chapanduka   +3 more
wiley   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde, Yendry Ventura Carmenate, Vianed Marsan Suarez, Yandy Marx Castillo Aleman, Imilla Casado Hernandez, Rachely Hernandez Corrales   +5 more
wiley   +1 more source

Coexistence of immunophenotypically normal and aberrant mast cells in patients with clonal mast cell diseases associates with more indolent subtypes and less severe disease characteristics

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Aberrant antigen expression on mast cells (MCs) is one of the most accurate diagnostic markers for clonal MC diseases (CMCD). Although the coexistence of normal and pathologic MCs is frequently seen, the disease characteristics associated with it have been minimally investigated.
Abdulrazzaq Alheraky, Kees Meijer, Marije Nijk, Saskia K. Klein, Hanneke N. G. Oude Elberink, Ido P. Kema, André B. Mulder   +6 more
wiley   +1 more source

Evaluation of a multiple myeloma synthetic cell mimic as an assay control for flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract The reliability of clinical flow cytometry assays hinges on the availability of robust assay controls that accurately reflect representative samples. Widely used conventional assay controls, such as cell lines, often fail to replicate the phenotypical and biophysical properties of representative primary samples resulting in gating variability ...
Dhong Hyun Lee, Mike Liu, Kanwal Palla, Subhanip Biswas, Swetha Pratyusha Gunturu, Brian Kerfs, Kristine Valenteros, Sarah Kotanchiyev, Shari Kaiser, Justine Dell'Aringa   +9 more
wiley   +1 more source

Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus on its management, challenged by chronic CMV infection

Frontiers in Immunology
BackgroundCommon variable immune deficiency (CVID) is the most prevalent inborn error of immunity (IEI), marked by diverse clinical-immunological phenotypes and significant immune-dysregulation, including granulomatous lymphocytic interstitial lung ...
Mattia Moratti, Mattia Moratti, Gioacchino Schifino, Francesco Baccelli, Francesco Baccelli, Simona Ferrari, Elisabetta Magrini, Mirna Bassi, Aldo Guerrieri, Maurizio Zompatori, Marcello Lanari, Marcello Lanari, Francesca Conti, Francesca Conti   +13 more
doaj   +1 more source

A case of juvenile myelomonocytic leukemia presenting with a B-lymphoblastic immunophenotype

, 2001
Juvenile myelomonocytic leukemia (JMML) represents no more than 2% of leukemias in children. To facilitate the diagnosis of this pathology, centralized diagnostic facilities have been established in our country.
D. LONGONI, F. MONTI, P. SACCHINI, BASSO, GIUSEPPE, L. SAINATI, V. VECCHI   +5 more
core  

Morphology, immunophenotype and viability of adipose-derived cells.

, 2016
The morphology, viability and immunophenotype of adipose-derived cells during passaging. ADSCs have fibroblastic features at P1, and P4. (A) The cell viability was confirmed by flow cytometry analysis. (B) The viability of ADSCs.
Hussein Hashim (3123123), Mayssam Moussa (3123120), Oula El Atat (3123105), Nabil Hokayem (3123111), George Hilal (714741), Joelle Abou-Ghoch (3123126), Nada Alaaeddine (714736), Clara Hebbo (3123114), Diane Antonios (3123117), Rim Serhal (3123108)   +9 more
core   +1 more source

A practical difference from the normal approach to evaluate natural killer (NK) cells and NK cell neoplasms by flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Natural killer (NK) cell neoplasms span indolent to highly aggressive entities, and flow cytometric immunophenotyping is central to their detection and classification. However, distinguishing reactive from neoplastic NK cell expansions can be challenging because NK cells lack somatically recombined antigen receptors, and reactive states may ...
Aaron J. Wilk, Afshin Shameli, Erik Ames, Jonathan R. Fromm, Bartosz Grzywacz, Min Shi, Sindhu Cherian, Jean Oak   +7 more
wiley   +1 more source

Machine learning applied to atopic dermatitis transcriptome reveals distinct therapy‐dependent modification of the keratinocyte immunophenotype

Background: atopic dermatitis (AD) arises from a complex interaction between an impaired epidermal barrier, environmental exposures, and the infiltration of T helper (Th)1/Th2/Th17/Th22 T cells.
Ardern-Jones, Michael, Clayton, Kalum, Bernal, Sofia Sirvent, Davies, James David, Reading, Isabel, Douilhet, Gemma, Lim, Fei Ling, Polak, Marta, Pulido, Andres Vallejo   +8 more
core   +1 more source