Results 241 to 250 of about 487,581 (283)

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Progranulin promotes glioma progression via interaction with cathepsin D and serves as a diagnostic and prognostic biomarker. [PDF]

Discov Oncol
Zhao C, Guo J, Zhou Z, Huang X, Hai Y, Gao W, Chen C, Dong G, Cai H, Li S.   +9 more
europepmc   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Histone fold domain positioning dictates cotranslational heterodimeric assembly of paralogous TAF12/TAF12L in Candida albicans. [PDF]

J Biol Chem
Bhardwaj V, Swanson S, Florens L, Washburn MP, Workman JL, Natarajan K.   +5 more
europepmc   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Identification of serine/arginine-rich splicing factor 1-interacting proteins in Plasmodium berghei. [PDF]

Malar J
Niikura M, Koyama Y, Fukuda Y, Kato K, Fukutomi T.   +4 more
europepmc   +1 more source

RING1B-BMI1 catalyzed dynamic H2AK119ub1 modification in response to sonic hedgehog signalling during pancreatic differentiation of human embryonic stem cells. [PDF]

Sci Rep
Dumasia NP, Pethe PS.
europepmc   +1 more source

Lactylation-driven <i>NSUN2</i>-mediated RNA m5C modification promotes perineural invasion in pancreatic cancer. [PDF]

Theranostics
Huang T, Hu C, Chen H, Jiang H, Li T, Tian Q, He R, Yuan Y, Jiang Y, Zhou Y, Lin Q, Li Z, Xiao M, Wei X, Chen R, Zheng S.   +15 more
europepmc   +1 more source

Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling. [PDF]

Nat Commun
Zhao L, He Z, Sun Y, Sun M, Liu Z, Zhou Z, Qi L, Luo Y, Ji Y, Liang T.   +9 more
europepmc   +1 more source