Results 211 to 220 of about 234,838 (300)

Human P301L tau expression in mice alters neuronal excitability independent of neurodegeneration. [PDF]

Front Neurosci
Dunton KL, Monchal H, Achorn BE, Mandé-Niedergang B, Roucard C, Roche Y, Evrard A, Menniti FS.   +7 more
europepmc   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

Determination of Expression and Relationships of Nedd4-Related E3 Ubiquitin Ligase-2 (NEDL2) and Ubiquitin Proteasome System Proteins in Developing Rat Pancreatic Tissue. [PDF]

Anat Histol Embryol
Corumluoglu I, Alimogullari E, Sacik U.
europepmc   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Effects of carnosic acid on renal injury-related parameters and iNOS immunoreactivity in an experimental model of contrast-associated acute kidney injury. [PDF]

Ren Fail
Küçükyağcı N, Salt Ö, Sayhan MB, Aydoğdu N, Taştekin E, Çeliktürk E, Seçgin Sayhan E.   +6 more
europepmc   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Immunohistochemical evaluation of apelin and VEGF expression in cortisol-producing adrenal adenomas. [PDF]

BMC Endocr Disord
Çalişkan Burgucu H, Günler T, Ömeroğlu E, Ünlü Y, Aksu O.   +4 more
europepmc   +1 more source

Cost‐Effective Ti/Al/Ni Multilayer Neural Probes With In Vivo Recording Performance Comparable to Ti/Au Neural Probes

Advanced Electronic Materials, EarlyView.
In this study, we developed a cost‐efficient neural probe by replacing traditional gold with an aluminum‐based Ti/Al/Ni multilayer stack. Optimizing this metal architecture suppressed oxidation and ensured robust electrical stability, achieving signal quality comparable to standard gold probes. It enables a highly accessible and economical solution for
Sehwan Park, Minseok Kim, Giheon Kim, Seungjun Lee, Haeyun Lee, Namsun Chou, Hyogeun Shin   +6 more
wiley   +1 more source

Serum Chemerin Concentrations and Tissue Immunoreactivity in Colorectal Adenoma and Colorectal Cancer: An Exploratory Case-Control Study. [PDF]

Diagnostics (Basel)
Szredzki P, Szredzka A, Belina A, Marlicz M, Podlasek M, Guzik P, Góra T, Koulaouzidis A, Marlicz W, Skonieczna-Żydecka K, Kukla M.   +10 more
europepmc   +1 more source