Results 131 to 140 of about 392,479 (342)

The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT

Efficacy and Mechanism Evaluation
Background Long-term surviving liver transplant recipients can spontaneously develop operational tolerance, which allows them to completely discontinue their immunosuppression, but we lack validated tools to predict the likelihood of rejection following ...
Julien Vionnet, Rosa Miquel, Juan G Abraldes, Juan-Jose Lozano, Pablo Ruiz, Miquel Navasa, Aileen Marshall, Frederik Nevens, William Gelson, Joanna Leithead, Steven Masson, Elmar Jaeckel, Richard Taubert, Phaedra Tachtatzis, Dennis Eurich, Kenneth Simpson, Eliano Bonaccorsi-Riani, James Ferguson, Alberto Quaglia, Maria Elstad, Marc Delord, Abdel Douiri, Alberto Sánchez-Fueyo   +22 more
doaj   +1 more source

Targeting immunosuppression by Tregs with monoclonal antibodies against GARP [PDF]

, 2016
Stéphanie Liénart, Julie Stockis, Olivier Dedobbeleer, Sophie Lucas   +3 more
openalex   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Supplementary Material for: Treatment of Pemphigus Vulgaris and Foliaceus with Adjuvant Rituximab Compared to Immunosuppression Alone: Real-Life Experience

, 2020
Igor Snast, Ludwig Spitzer, Emmilia Hodak, Assi Levi, Daniel Mimouni, Yael A. Leshem   +5 more
openalex   +1 more source

Polymyxin B-immobilized fiber hemoperfusion therapy improves sepsis-related immunosuppression [PDF]

, 2014
Akifumi Kimura, Satoshi Ono, Shuichi Hiraki, Risa Takahata, Hironori Tsujimoto, Manabu Kinoshita, Suefumi Aosasa, Kazuo Hatsuse, Daizoh Saitoh, Kazuo Hase, Junji Yamamoto   +10 more
openalex   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Immunosuppression-induced diabetes mellitus [PDF]

, 2002
Iain MacPhee
openalex   +1 more source

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu, Fa‐Peng Zhang, Chao Qin, Zhi‐Xiao Song, Cai‐Ni Yang, Shu‐Sheng Lin, Xian‐Huan Yu, Wen‐Rui Wu, Chao‐Qun Liu, Chao Liu, Lei‐Bo Xu   +10 more
wiley   +1 more source

Advocating for the recognition of underlying immunosuppression in critical illness

EClinicalMedicine
Summary: Immunosuppression, characterised by impaired immune function, significantly influences infection risk and ICU admissions in critically ill patients.
Ignacio Martin-Loeches, Sascha David, Frédéric Pène, Louis Kreitmann, Lene Russel, Kathryn Puxty, João Santos Silva, Ana Vagos Mata, Ben Creagh-Brown, Pedro Castro, Jorge Salluh, Loreto Vidaur-Tello, Saad Nseir, Elie Azoulay   +13 more
doaj   +1 more source

The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus

, 2013
Michael Look, W. Mark Saltzman, Joe Craft, Tarek M. Fahmy   +3 more
openalex   +2 more sources