Results 121 to 130 of about 458,490 (361)

Supplementary Table S5 from Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3⁺ Cancer Cells in Locally Advanced Pancreatic Cancer

, 2023
Yves Boucher, Jessica M. Posada, Sonu Subudhi, Ashwin S. Kumar, Spencer R. Rosario, Liqun Gu, Heena Kumra, Mari Mino–Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernández‐del Castillo, Theodore S. Hong, Mikäel J. Pittet, Rakesh K. Jain   +17 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Immunosuppression and herpes viral reactivation in intensive care unit patients: one size does not fit all

Critical Care, 2017
Julien Textoris, François Mallet
doaj   +1 more source

Pulmonary arterial hypertension in systemic lupus erythematosus may benefit by addition of immunosuppression to vasodilator therapy: an observational study [PDF]

, 2015
Sirisha Kommireddy, Srinivas Bhyravavajhala, Kishorebabu Kurimeti, Srinivasa Chennareddy, S Kanchinadham, Irlapati Rajendra Vara Prasad, Liza Rajasekhar   +6 more
openalex   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT

Efficacy and Mechanism Evaluation
Background Long-term surviving liver transplant recipients can spontaneously develop operational tolerance, which allows them to completely discontinue their immunosuppression, but we lack validated tools to predict the likelihood of rejection following ...
Julien Vionnet, Rosa Miquel, Juan G Abraldes, Juan-Jose Lozano, Pablo Ruiz, Miquel Navasa, Aileen Marshall, Frederik Nevens, William Gelson, Joanna Leithead, Steven Masson, Elmar Jaeckel, Richard Taubert, Phaedra Tachtatzis, Dennis Eurich, Kenneth Simpson, Eliano Bonaccorsi-Riani, James Ferguson, Alberto Quaglia, Maria Elstad, Marc Delord, Abdel Douiri, Alberto Sánchez-Fueyo   +22 more
doaj   +1 more source

The Effect of Immunosuppressive Treatment on Torque Teno Virus Load in Lung Transplant Recipients: A Preliminary Study

Viruses
After transplantation, systematically monitoring and assessing the risk of transplanted organ rejection is crucial. Current methods involving immunosuppressant monitoring, the assessment of organ function, and biopsies are insufficient for predicting ...
Marek Ochman, Dagmara Galle, Anna Kowal, Magdalena Królikowska, Fryderyk Zawadzki, Anita Stanjek-Cichoracka, Anna Łaszewska, Elżbieta Chełmecka, Tomasz Hrapkowicz   +8 more
doaj   +1 more source

Assessment of the Degree of Immunosuppression Measured by Residual Expression of Genes Regulated by T-Cell Nuclear Factor (NFAT-RGE) in Lung Transplant Recipients [PDF]

M. Boada Pérez, Victoria Ruiz, Marta Erro, Piedad Ussetti, Silvia Rosado, Raquel Castejón, Martin Aguilar, E. Revilla, C. Bravo Masgoret, B. Saez Gimenez, Moises Zapata, C. Berastegui Garcia, M. Lopez Meseguer, Yolanda Villena-Ortiz, J. Vima Bofarull, Vı́ctor Monforte, S. Gomez   +16 more
openalex   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source