Results 141 to 150 of about 514,735 (343)

Advances in the understanding and treatment of sepsis-induced immunosuppression

Nature Reviews Nephrology, 2018
F. Venet, G. Monneret
semanticscholar   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

The Induction and Abolition of Specific Immunosuppression of Heart Allografts in Rats by Use of Donor Blood and Cyclophosphamide [PDF]

, 1975
Richard L. Marquet, GERARD A. HEYSTEK
openalex   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Immunosuppression by co-trimoxazole. [PDF]

, 1972
Heikki Arvilommi, M. Vuori, A. Salmi
openalex   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Immunosuppression and Temporary Skin Transplantation in the Treatment of Massive Third Degree Burns

, 1975
John F. Burke, William C. Quinby, Conrado C. Bondoc, A. Benedict Cosimi, Paul S. Russell, S. K. Szyfelbein   +5 more
openalex   +2 more sources

Carcinogenic action of anticancer drugs with special reference to immunosuppression [PDF]

, 1977
D. Schmähl
openalex   +1 more source

Iatrogenic Alterations of Immunologic Surveillance in Man and Their Influence on Malignancy [PDF]

, 1971
Agosin M., Albert D., Alford T. C, Allison A. C, Alpert E., Alpert M. E., Anigsten L., Bach F. H., Baserga R., Bekkum D. W., Berman C., Bortin M. M., Bremberg S., Burnet F. M., Burnet F. M., Burnet F. M., Burnet F. M., Casey T. P., Davis R. C., Dent P. B., Deodhar S. D., Doak P. B., Doll R., Epstein R. B., Fisher E. R., Foley E. J., Foley E. J., Fortner J. G., Grant G. A., Gustafson E. G., Hellman K., Hirsch M. S., Huber J., Immunology and Cancer, Isojima S., Jensen C O., Kay S., Law L. W., MacLean L. D., Mandel M.A., Marchioro T. L., Martin D. C, Martinez C, Mathe G., Mathe G., McIntosh D. A., McKhann C. F., Miller J. F. A. P., Moore G. E., Muizniks H. W., Page A. R., Penn I., Penn I., Penn I., Penn I., Prehn R. T., Pritzker K. P. H., Rabbat A. G., Santos G. W., Santos G. W., Schwartz R., Simmons R. L., Sjogren H. O., Snell G. D., Southam C. M., Speck B., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Starzl T. E., Tallent M. B., Thomas L., Toolan H.W., Tunner W. S., Tyler A., Vredevoe D. L., Weiler E., Wilson R. E., Zukoski C. F., Zukoski C. F.   +85 more
core   +1 more source

Role of Tunneling Nanotubes in Arachidonic Acid Transfer and Macrophage Function Reprogramming in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
Tunneling nanotubes facilitate the transfer of long‐chain fatty acids, primarily arachidonic acid, from tumor cells to macrophages, leading to lipid accumulation and activation of the PI3K‐Akt pathway. This drives a shift from the anti‐tumor CD5L⁺ phenotype to a pro‐tumor TREM2⁺ phenotype.
Meiru Chen, Shangyumeng Zhao, Xiaoli Xie, Jiaqi Wang, Miao Su, Lixian Zhang, Ruolin Cui, Dongqiang Zhao   +7 more
wiley   +1 more source