Results 141 to 150 of about 392,479 (342)

Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes

, 2021
Francesca Ferraro, Christopher A. Miller, Keegan A. Christensen, Nichole Helton, Margaret O’Laughlin, Catrina C. Fronick, Robert S. Fulton, Jessica Kohlschmidt, Ann‐Kathrin Eisfeld, Clara D. Bloomfield, Sai Mukund Ramakrishnan, Ryan B. Day, Lukas D. Wartman, Geoffrey L. Uy, John S. Welch, Matthew Christopher, Sharon E. Heath, Jack Baty, Matthew J. Schuelke, Jacqueline E. Payton, David H. Spencer, Michael P. Rettig, Daniel C. Link, Matthew J. Walter, Peter Westervelt, John F. DiPersio, Timothy J. Ley   +26 more
openalex   +2 more sources

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Sepsis-induced immunosuppression: mechanisms, biomarkers and immunotherapy

Frontiers in Immunology
Sepsis, a life-threatening organ dysfunction resulting from a dysregulated host response to infection, initiates a complex immune response that varies over time, characterized by sustained excessive inflammation and immunosuppression.
Xun Gao, Xun Gao, Shijie Cai, Shijie Cai, Xiao Li, Xiao Li, Guoqiu Wu, Guoqiu Wu   +7 more
doaj   +1 more source

Belatacept-versus Cyclosporine-Based Immunosuppression in Renal Transplant Recipients with Pre-existing Diabetes

, 2011
Lionel Rostaing, H. H. Neumayer, Rafael Reyes‐Acevedo, Barbara A. Bresnahan, Sander Florman, Š Vı́tko, Michael Heifets, Jun Xing, Dolca Thomas, Flavio Vincenti   +9 more
openalex   +2 more sources

P402 Is co-trimoxazole prophylaxis necessary for Inflammatory Bowel Disease patients receiving triple immunosuppression? [PDF]

, 2021
Gregory J. Phillips, C Moore-Gillan, Zameer Mohamed, P Mikin, S. Peake, Lucy Hicks   +5 more
openalex   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
wiley   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Delayed persistence of elevated monocytic MDSC associates with deleterious outcomes in septic shock: a retrospective cohort study

Critical Care, 2020
Louis Waeckel, Fabienne Venet, Morgane Gossez, Céline Monard, Thomas Rimmelé, Guillaume Monneret   +5 more
doaj   +1 more source

Endogenous retrovirus-encoded Syncytin-2 contributes to exosome-mediated immunosuppression of T cells† [PDF]

, 2019
Adjimon Gatien Lokossou, Caroline Toudic, Phuong Nguyen, Xavier Elisseeff, Amandine Vargas, Éric Rassart, Julie Lafond, Line Leduc, Steve Bourgault, Caroline Gilbert, Tatiana Scorza, Jorge M. Tolosa, Benoı̂t Barbeau   +12 more
openalex   +1 more source