Results 181 to 190 of about 521,863 (391)

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults

open access: yesAdvanced Science, EarlyView.
This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng   +16 more
wiley   +1 more source

Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment

open access: yesAdvanced Science, EarlyView.
Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV‐irradiated keratinocytes.
Lu Liu   +16 more
wiley   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu   +10 more
wiley   +1 more source

Intracellular calcium signaling and phospho-antigen measurements reveal functional proximal TCR activation in lymphocytes from septic shock patients

open access: yesIntensive Care Medicine Experimental, 2019
Charles de Roquetaillade   +9 more
doaj   +1 more source

Immunosuppression by co-trimoxazole. [PDF]

open access: bronze, 1972
Heikki Arvilommi, M. Vuori, A. Salmi
openalex   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

open access: yesAdvanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang   +13 more
wiley   +1 more source

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