Results 181 to 190 of about 392,479 (342)

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Consensus-based Recommendations on the Management of Immunosuppression After Squamous Cell Carcinoma Diagnosis in Kidney Transplant Recipients: An International Delphi Consensus Statement. [PDF]

Transplant Direct
Whitley MJ, Wang JX, Chapman J, de Vries APJ, Chandran S, Glennon CM, Madariaga HM, Carroll RP, Booth J, Concepcion B, Couzi L, De Serres SA, Doyle A, Forbes S, Gleadle JM, Griffin S, Gunaratnam L, Gupta G, Ho J, Hughes P, Isbel N, Jegatheesan DK, Jones G, Kuypers D, Lee B, Lim W, Mason P, Meneghini M, Owoyemi I, Rao S, Salama A, Sharif A, Thaunat O, Thuraisingham R, Wyburn K, Yabu JM, Jambusaria-Pahlajani A, Bottomley MJ, Arron ST.   +38 more
europepmc   +1 more source

PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression

Clinical Cancer Research, 2017
Shiping Jiao, W. Xia, H. Yamaguchi, Yongkun Wei, Mei-Kuang Chen, Jung-Mao Hsu, J. Hsu, Wen-Hsuan Yu, Yi Du, Heng-Huan Lee, Chia‐Wei Li, C. Chou, Seung-Oe Lim, Shih-Shin Chang, J. Litton, B. Arun, G. Hortobagyi, M. Hung   +17 more
semanticscholar   +1 more source

Induction of Disseminated Virulent Cytomegalovirus Infection by Immunosuppression of Naturally Chronically Infected Wild Mice [PDF]

, 1974
Murray B. Gardner, J. E. Officer, John C. Parker, John D. Estes, Robert W. Rongey   +4 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Enzymatic and microenvironmental regulation in adenosine metabolism-mediated immunosuppression. [PDF]

Front Immunol
Li C, Chen L, Li Z, Liang L, Lou B.
europepmc   +1 more source

Immunosuppression for hyperinflammation in COVID-19: a double-edged sword?

The Lancet, 2020
A. Ritchie, A. Singanayagam
semanticscholar   +1 more source

Induction Immunosuppression Strategies and Long-Term Outcomes after Heart Transplantation [PDF]

, 2016
Daniel Ansari, Josef Stehlik, Lars H. Lund, Bodil Andersson, Leah B. Edwards, Johan Nilsson   +5 more
openalex   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source