Results 191 to 200 of about 282,999 (266)

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Comment on: "The role of SIGLEC9 in immunosuppression and prognosis in cervical cancer". [PDF]

Clinics (Sao Paulo)
de Oliveira HF, de Souza FD.
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Systemic Immunosuppression to Reduce Surgical Intervention in ANCA-Negative Subglottic Stenosis. [PDF]

Laryngoscope
Benshetrit G, McAdoo S, Kuchai R, Pusey C, Sandhu G, Al-Yaghchi C.   +5 more
europepmc   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Decoding Immune Dysregulation in Sepsis Through Extracellular Vesicles: A Path to Precision Medicine. [PDF]

Pharmaceutics
Schiavello M, Vizio B, Bosco O, Dini C, Pivetta E, Morello F, Lupia E, On Behalf Of The Sepsis In Emergency Medicine Study Group.   +7 more
europepmc   +1 more source

Beyond the Graft: Optimizing Post-Transplant Care in Primary Sclerosing Cholangitis. [PDF]

J Clin Med
Becchetti C, Viganò R, Aprile F, Scaravaglio M, Vitale G, Perricone G, Mazzarelli C, Vangeli M, Belli LS, Carbone M, Morelli MC.   +10 more
europepmc   +1 more source

Atypical Location of Noninfectious Esophageal Ulceration in a Chronically Immunosuppressed Patient. [PDF]

ACG Case Rep J
Rivera Hernández TN, Sundi SH, Singh R, Habashi S.   +3 more
europepmc   +1 more source