Results 191 to 200 of about 353,556 (317)

Bioengineering Platelets Presenting PD‐L1, Galectin‐9 and BTLA to Ameliorate Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
IFN‐γ‐primed platelets enriched with immunosuppressive ligands (PD‐L1, PD‐L2, BTLA, and Gal‐9) are shown to induce T cell exhaustion and apoptosis, preserving β‐cell function and preventing hyperglycemia progression in type 1 diabetes. IFN‐γ platelets also promote Treg expansion, macrophage polarization, and β‐cell proliferation, offering a promising ...
Yumeng Ma   +14 more
wiley   +1 more source

Herbal Medicines for Immunosuppression

open access: yesIranian Journal of Allergy, Asthma and Immunology, 2012
Herbal medicines have been used for centuries to treat different illnesses. Among more than 20,000 herbal medicines available for humans, a limited number have sufficiently been studied and numerous remained to be investigated for their efficacy in ...
Zahra Amirghofran
doaj  

THYMECTOMY AS IMMUNOSUPPRESSION IN UREMIC PATIENTS

open access: bronze, 1975
Sven Arvid Birkeland   +4 more
openalex   +1 more source

Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD‐1 Blockade in MSS Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
xxxx. Abstract Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored.
Qi‐Long Wang   +16 more
wiley   +1 more source

Superficial radiation therapy for nonmelanoma skin cancer: A review

open access: yesDermatological Reviews, Volume 3, Issue 6, Page 409-417, December 2022., 2022
Abstract Background The high prevalence of nonmelanoma skin cancer (NMSC) has become a global health‐care burden. Various modalities have been established to treat NMSC, with surgery being the mainstay approach. Superficial radiation therapy (SRT) has been in use for over a century to treat various conditions. Recent discussion among the dermatological
Haowei Han   +5 more
wiley   +1 more source

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo   +10 more
wiley   +1 more source

New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study

open access: yesEndocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Metformin’s pleomorphic effects may be beneficial in sepsis and septic shock, but its impact remains controversial. Our study is the first to show a significant association between metformin and lactate kinetics in sepsis or septic shock, with a larger decrease in lactate after admission.
Nina Van Moorter   +4 more
wiley   +1 more source

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