Results 221 to 230 of about 556,132 (392)

Data from Antagonizing Integrin β3 Increases Immunosuppression in Cancer

, 2023
Xinming Su, Alison K. Esser, Sarah R. Amend, Jingyu Xiang, Yalin Xu, Michael H. Ross, Gregory C. Fox, Takayuki Kobayashi, Veronica Steri, Kirsten Roomp, Francesca Fontana, Michelle A. Hurchla, Brett L. Knolhoff, Melissa A. Meyer, Elizabeth A. Morgan, Julia C. Tomasson, Joshua S. Novack, Wei Zou, Roberta Faccio, Deborah V. Novack, Stephen Robinson, Steven L. Teitelbaum, David G. DeNardo, Jochen G. Schneider, Katherine N. Weilbaecher   +24 more
openalex   +1 more source

CD169+ Macrophage‐Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication

Advanced Science, EarlyView.
A CD169+ macrophage‐targeted immunomodulator (G‐LNP@S‐D) is developed to co‐deliver a SHP2 inhibitor and STING agonist, thereby restoring phagocytic function, enhancing antigen presentation by CD169+ macrophages, and promoting T cell priming to eradicate lymphatic metastasis.
Xiayun Chen, Lichong Lu, Yibin Liu, Ziqi Liang, Jianqiao Li, Zhouchuan Shao, Youzhi Tang, Jianhua Zou, Shiying Li, Xiaoyuan Chen   +9 more
wiley   +1 more source

Drug-Induced Partial Immunosuppression for Preclinical Human Tumor Xenograft Models. [PDF]

Cancers (Basel)
Gorbushin AK, Luzan NA, Kakhanova VD, Koshmanova AA, Grek DS, Voronkovskii II, Farniev VM, Melikhova ES, Lukyanenko KA, Veprintsev DV, Morozov EV, Dymova MA, Kuligina EV, Pryakhin EA, Richter VA, Styazhkina EV, Lipetskaya EA, Garkusha TA, Zamay TN, Kolovskaya OS, Narodov AA, Kumeiko VV, Berezovski MV, Kichkailo AS.   +23 more
europepmc   +1 more source

The impact of calcineurin inhibitors on coronary artery spasm — costs of effective immunosuppression

, 2017
Norbert Kwella, Beata Januszko‐Giergielewicz, Katarzyna Pietraszewska, L Adadyński   +3 more
openalex   +1 more source

Myeloid immunosuppression and immune checkpoints in the tumor microenvironment

Cellular & Molecular Immunology, 2019
Kyohei Nakamura, M. Smyth
semanticscholar   +1 more source

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Immunosuppressive Therapy in Pediatric Kidney Transplantation: Evolution, Current Practices, and Future Directions. [PDF]

Biomedicines
Al Riyami MS, Al Gaithi B, Al Kalbani N, Al Saidi S.   +3 more
europepmc   +1 more source

Supplementary Table S3 from Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3⁺ Cancer Cells in Locally Advanced Pancreatic Cancer

Yves Boucher, Jessica M. Posada, Sonu Subudhi, Ashwin S. Kumar, Spencer R Rosario, Liqun Gu, Heena Kumra, Mari Mino-Kenudson, Nilesh P Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P Ryan, Carlos Fernandez-del Castillo, Theodore S. Hong, Mikaël J. Pittet, Rakesh K. Jain   +17 more
openalex   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Immune Monitoring Goes Viral - Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation. [PDF]

Transpl Int
Doberer K, Kapps S, Haupenthal F, Bond G.   +3 more
europepmc   +1 more source