Results 221 to 230 of about 392,479 (342)

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.

Cancer Cell, 2015
B. Özdemir, Tsvetelina Pentcheva-Hoang, Julienne L. Carstens, Xiaofeng Zheng, Chia-Chin Wu, T. Simpson, Hanane Laklai, H. Sugimoto, Christoph Kahlert, S. Novitskiy, A. De Jesus-Acosta, Padmanee Sharma, P. Heidari, U. Mahmood, L. Chin, H. Moses, V. Weaver, A. Maitra, J. Allison, Valerie S. LeBleu, R. Kalluri   +20 more
semanticscholar   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Immunosuppression in patients who die of sepsis and multiple organ failure.

Journal of the American Medical Association (JAMA), 2011
J. Boomer, K. To, Kathy C Chang, O. Takasu, D. Osborne, A. Walton, T. Bricker, S. Jarman, D. Kreisel, A. Krupnick, Anil Srivastava, P. Swanson, Jonathan M. Green, R. Hotchkiss   +13 more
semanticscholar   +1 more source

Supplementary Data from Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma

Deepak Rohila, In Hwan Park, Timothy V. Pham, Jonathan Weitz, Tatiana Hurtado de Mendoza, Suresh Madheswaran, Mehreen Ishfaq, Cooper Beaman, Elisabette Tapia, Siming Sun, Jay Patel, Pablo Tamayo, Andrew M. Lowy, Shweta Joshi   +13 more
openalex   +1 more source

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang   +14 more
wiley   +1 more source

Bone complications after hand and face transplantation: Mechanisms and management. [PDF]

JPRAS Open
Dirican O, Sazoglu B, Demir Z, Kodali NA, Janarthanan R, Kulahci Y, Zor F, Gorantla VS.   +7 more
europepmc   +1 more source

Referee report. For: Donor-derived circulating cell-free DNA as a rejection biomarker and modulator of immunosuppression following liver transplantation: A randomized controlled trial [version 1; peer review: 1 approved]

Roma Raj
openalex   +1 more source

Injury-induced immunosuppression: are we finally on the right track?

, 2017
Stefano Busani, Andrea Cossarizza, Massimo Girardis   +2 more
openalex   +2 more sources

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

Paradigm shift: PRRSV-mediated active remodeling of the host immune system-From epigenetic domestication to functional hijacking. [PDF]

Front Microbiol
Duan D, Cao C, Qiu L, Li X, Chen H.
europepmc   +1 more source