Results 231 to 240 of about 458,490 (361)

5-fluorouracil-induced up-regulation of exosomal PD-L1 causing immunosuppression in gastric cancer patients

, 2018
Zhenya Min, Fan Yi-Bo, CA Xiao-fang, H. Kezuo, Xiujuan Qu   +4 more
openalex   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Dynamics of the microbiota in patients with Clostridioides difficile: Recurrence, treatment, sex, and immunosuppression. [PDF]

PLoS Pathog
Ventero MP, Herrero R, Tyshkovska I, Valverde-Fredet MD, Rodríguez JC, Rodríguez-Fernández M, González-De-La-Aleja P, Trigo M, Parra M, Aller AI, Otero S, Espindola-Gomez R, Ramos JM, León EM, García M, Navarrete-Lorite MN, Llenas-García J, Portillo I, Jover F, Tasias M, Caston JJ, Gil C, Vinuesa-Garcia D, Gomez-Ayerbe C, Martínez Marcos FJ, Merchante N, De Lucas EM.   +26 more
europepmc   +1 more source

Glycosylated GM-CSF expands B-1b cells and B-1b plasma cells and programs them for immunosuppression

Haisam Alattar, Arpa Aintablian, I Eckert, Haroon Shaikh, Laura Cyran, Zheng Liu, Bhupesh Kumar Prusty, Fabian Imdahl, Elisabeth Zinser, Andreas Beilhack, Nadine Hövelmeyer, B. Clausen, Tom Gräfenhan, Florian Erhard, Manfred B. Lutz   +14 more
openalex   +1 more source

Addition of Belatacept to Tacrolimus-Mycophenolate-Prednisone (Quadruple Immunosuppression) in Kidney Transplant Recipients with Donor Specific Antibodies and/or Antibody Mediated Rejection [PDF]

Laura Cotiguala, A Przybylski, Yu Tian, Reynold I. Lopez‐Soler, Chardria Trotter, Erin Mahoney, Dietmar Mattes, Rupinder Kaur Sodhi   +7 more
openalex   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Systemic Lupus Erythematosus With IgA Nephropathy: Challenges in Diagnosis and Management. [PDF]

Am J Case Rep
Shah M, Malik F, Shah M, Patel MD, Pathakjee R, Pandya S.   +5 more
europepmc   +1 more source

The surgical implications of the posttransplant lymphoproliferative disorders. [PDF]

, 1991
Boillot, O, Gordon, RD, Marino, I, Mazzaferro, V, Nalesnik, MA, Scotti-Foglieni, C, Starzl, TE, Stieber, AO   +7 more
core  

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source