Results 231 to 240 of about 514,735 (343)

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Discordance between biochemical and histological severity in persistent immune checkpoint inhibitor induced liver injury. [PDF]

BMJ Case Rep
Attree C, Saibil SD, Fischer S, Cunningham M.   +3 more
europepmc   +1 more source

FK506 IN CLINICAL ORGAN-TRANSPLANTATION [PDF]

, 1991
ABUELMAGD, K, ARMITAGE, J, BRONSTER, O, FUNG, JJ, GORDON, R, JAIN, A, JORDAN, M, KORMOS, R, MARTIN, M, SELBY, R, SHAPIRO, R, STARZL, TE, STIEBER, A, TODO, S, TZAKIS, A   +14 more
core  

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia

New England Journal of Medicine, 2017
D. Townsley, P. Scheinberg, T. Winkler, R. Desmond, B. Dumitriu, O. Rios, B. Weinstein, Janet Valdez, J. Lotter, Xingmin Feng, M. Desierto, Harshraj Leuva, M. Bevans, Colin O. Wu, A. Larochelle, K. Calvo, C. Dunbar, N. Young   +17 more
semanticscholar   +1 more source

Constitutive Androstane Receptor in Macrophages Regulates Toll‐Like Receptor 4‐Mediated Innate Immune Responses Against Endotoxemic Liver Injury

Advanced Science, EarlyView.
The present study uncovers a novel role of constitutive androstane receptor (CAR) in inflammation‐mediated damage. CAR activation in macrophages inhibits proinflammatory macrophages by interacting with Tlr4, which protects against endotoxemic liver injury.
Renjie Cao, Tingting Zhao, Ying Wang, Shaofei Song, Yuan Li, Mengling Hou, Yanxin Zhang, Sengpeng Wong, Siqi Wang, Yuran Wang, Hong Peng, Min Huang, Yiming Jiang   +12 more
wiley   +1 more source

Semilunar Valve Function After Rejection in Heart Transplant Recipients: Implications for Partial Heart Transplantation. [PDF]

Pediatr Transplant
Dudley S, Conaway M, McCulloch M, Haregu F.   +3 more
europepmc   +1 more source

Immunosuppression in patients who die of sepsis and multiple organ failure.

Journal of the American Medical Association (JAMA), 2011
J. Boomer, K. To, Kathy C Chang, O. Takasu, D. Osborne, A. Walton, T. Bricker, S. Jarman, D. Kreisel, A. Krupnick, Anil Srivastava, P. Swanson, Jonathan M. Green, R. Hotchkiss   +13 more
semanticscholar   +1 more source

Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy

Advanced Science, EarlyView.
Programmable DNA framework captors effectively deplete circulatingtransforming growth factor‐β1 (TGFβ1) through fast systemic clearance and reshape the tumor immune microenvironment, alleviating immunosuppression to inhibit tumor progression. Abstract Efficient modulation of pivotal immune‐regulatory molecules to leverage the tumor microenvironment ...
Xiao Chen, Dunfang Liu, Jiahui Jin, Han Yao, Yao Sheng, Yarong Liu, Jingwei Sun, Yang Yang   +7 more
wiley   +1 more source

The Tumour Glyco-Code: Sialylation as a Mediator of Stromal Cell Immunosuppression in the Tumour Microenvironment. [PDF]

Eur J Immunol
O'Neill A, Zakaria N, Egan H, Treacy O, Hogan AM, O'Dwyer M, Hynes SO, Ryan AE.   +7 more
europepmc   +1 more source

PD‐L1‐Targeting Biomimetic Photoresponsive Thermosensitive Liposomes for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Tan et al. developed a platelet membrane‐coated, thermoresponsive liposome for targeted, light‐controlled delivery of fluorinated peptides that promotes programmed death‐ligand 1 degradation, induces tumor immunogenic cell death, suppresses solid tumors and metastases, and triggers durable immune memory, offering a promising strategy for peptide‐based ...
Manman Tan, Chengyu Shi, Guangyi Chi, Xinwan Su, Fangzhou Liu, Linyu Zhu, Guangqian Cheng, Xiangyi Chen, Meng Yu, Yijian Chen, Ying Wang, Yu Chen, ShuLing Yan, Wenfei Wu, Qingfeng Yan, Jianzhong Shao, Kai Wang, Xiangrui Liu, Min Zhou, Aifu Lin   +19 more
wiley   +1 more source