Results 261 to 270 of about 392,479 (342)

Case Report: Cutaneous <i>Mycobacterium chelonae</i> infection in a kidney transplant recipient with long-term immunosuppression and eculizumab therapy. [PDF]

Front Med (Lausanne)
Sukackiene D, Satkauskaite D, Sleivyte U, Vinikovas A, Ulianskaite G, Pamedys J, Raudonis T, Miglinas M.   +7 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Editorial: Advances in myeloid cell targeting for overcoming tumor immunosuppression. [PDF]

Front Immunol
Yan D, Yang Q, Zhou J.
europepmc   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

It never rains but pours: disseminated nocardiosis in a renal transplant patient from Nigeria - a case report. [PDF]

BMC Infect Dis
Whitehead T, Zaw HZ, Elliott I, Fry MJ, Jeffery K, Jones N, McCrae J, Stoesser N, Tsakok M, Wangrangsimakul T, Brook M, Angus BJ, Chan XHS.   +12 more
europepmc   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

CD4⁺ T cells stratification unveils a dynamic pathogen landscape in severe pneumonia: a targeted next-generation sequencing-based cohort study. [PDF]

Front Cell Infect Microbiol
Wang S, Yu Y, Lihe C, Sun L, Du N, Minglei Z.   +5 more
europepmc   +1 more source

Functional DeliverySystems for Targeting Tumor Heterogeneity:Reversing Immunosuppression and Modulating Cancer-Immune Interplay

Di Han (618795), Xin-Ru Liao (15285011), Qi-Yang Huang (20879873), Li-Jin Qi (20879876), Chang Xu (102022), Xiao-He Ren (6898688), Xiao-Yan He (80143), Tao Guo (126667), Yun Huang (169805), Xuan Pang (1899634), Xuesi Chen (539648), Xian-Zheng Zhang (1449169), Si-Xue Cheng (1604158)   +12 more
openalex   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source