Results 41 to 50 of about 6,220 (295)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Management of Refractory Lupus Nephritis [PDF]

European Medical Journal Nephrology, 2015
Despite the significant advances in the field, up to one-third of lupus nephritis (LN) patients still do not respond adequately to initial immunosuppressive treatment.
Antonis Fanouriakis, George Bertsias
doaj  

Wiener klinische Wochenschrift / Immunosuppressives and biologics during pregnancy and lactation : A consensus report issued by the Austrian Societies of Gastroenterology and Hepatology and Rheumatology and Rehabilitation

, 2019
An increasing and early-onset use of immunosuppressives and biologics has become more frequently seen among patients with inflammatory bowel diseases (IBD) and rheumatic disorders. Many women in their childbearing years currently receive such medications,
Sautner, Judith, Koch, Robert, Studnicka-Benke, Andrea, Weger, Wolfgang, Puchner, Rudolf, Gröchenig, Hans Peter, Reinisch, Sieglinge, Hermann, Josef, Puchner, Antonia, Juch, Herbert, Helmy-Bader, Yvonne, Dejaco, Clemens, Högenauer, Christoph   +12 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Should immunosuppressives be stopped in granulomatosis with polyangiitis (Wegener's granulomatosis) patients undergoing dialysis?

, 2012
Immunosuppressives are frequently stopped in patients with granulomatosis with polyangiitis (GPA) (Wegener's grantilomatosis)who develop end-stage renal disease.
Buyuktas, Deram, Tascilar, K., Yurdakul, S., Hatemi, G., Fresko, I.   +4 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Evolution of research in diagnosis and management of uveitis over four decades in India

Indian Journal of Ophthalmology
Uveitis and its complications are more common in the developing world, in which the condition occurs in up to 714 per 100,000 in the population and accounts for up to 25% of all blindness.
Jyotirmay Biswas, Sourabh Jadhav, Bhuvaneshwaran V Eswaran   +2 more
doaj   +1 more source

Sympathetic ophthalmia presenting with signs of frosted branch angiitis: Report of a case

Oman Journal of Ophthalmology, 2018
Sympathetic ophthalmia is an ocular inflammatory disease commonly associated with penetrating trauma. We report a case of sympathetic ophthalmia who had Dalen-Fuchs nodules on presentation and developed a frosted branch angiitis (FBA)-like picture which ...
Radha Annamalai, Jyotirmay Biswas
doaj   +1 more source

Clinical course of acute deep vein thrombosis of the legs in Behcet's syndrome

, 2020
Objectives: Lower extremity deep vein thrombosis (LEDVT) is a serious complication of Behcet's syndrome. Management constitutes mainly of administration of immunosuppressives, but the predictors of relapse and the optimal choice of immunosuppressives ...
HATEMİ, Gülen, MELİKOĞLU, Melike, HAMURYUDAN, Vedat, Cetinkaya, Firat, Tascilar, Koray, UĞURLU, Serdal, ÖZGÜLER, Yeşim, SEYAHİ, Emire, Yazici, Hasan   +8 more
core   +1 more source