Results 61 to 70 of about 6,220 (295)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Systemic sclerosis: Current concepts in pathogenesis and therapeutic aspects of dermatological manifestations

Indian Journal of Dermatology, 2013
Systemic sclerosis (SSc) is a chronic, multisystem connective tissue disease with protean clinical manifestations. Recent advances in understanding the pathogenic mechanisms have led to development of target-oriented and vasomodulatory drugs which play a
Vishalakshi Viswanath, Meghana M Phiske, Vinay V Gopalani   +2 more
doaj   +1 more source

Polyarteritis nodosa with genital necrosis

Urology Case Reports, 2020
Polyarteritis nodosa (PAN) is a multisystemic disease that is characterized by the presence of necrotizing vasculitis of small and medium-sized blood vessels. Genital compromise is rare.
Paula Grinstein, Lopez Silva Maximiliano, Yirula Lucas, Bernardo Norberto   +3 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Surgical management in patient with uveitis

Indian Journal of Ophthalmology, 2013
Surgery in the management of uveitis can be divided based on indication: either for therapeutic or can be for diagnostic purposes or to manage complications.
Somasheila I Murthy, Rajeev Reddy Pappuru, K Madhavi Latha, Sripathi Kamat, Virender S Sangwan   +4 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Current approach in the diagnosis and management of posterior uveitis

Indian Journal of Ophthalmology, 2010
Posterior uveitic entities are varied entities that are infective or non-infective in etiology. They can affect the adjacent structures such as the retina, vitreous, optic nerve head and retinal blood vessels. Thorough clinical evaluation gives a clue to
Sudharshan S, Ganesh Sudha, Biswas Jyotirmay   +2 more
doaj  

Clinico-Epidemiologic Profile and Response to Levocetirizine in Chronic Spontaneous Urticaria: A Retrospective Cohort Study from a Tertiary Care Center in North India

Indian Dermatology Online Journal
Background: Comprehensive long-term follow-up data regarding chronic spontaneous urticaria (CSU) among general populations, especially from the Indian subcontinent is scanty.
Raihan Ashraf, Anuradha Bishnoi, Hitaishi Mehta, Davinder Parsad, Muthu Sendhil Kumaran   +4 more
doaj   +1 more source

Periorbital dirofilariasis-Clinical and imaging findings: Live worm on ultrasound

Indian Journal of Ophthalmology, 2013
Ocular dirofilariasis is a zoonotic filariasis caused by nematode worm,Dirofilaria. We present a case of dirofilariasis affecting the upper eyelid in a 2-year-old child presenting as an acutely inflammed cyst, from southern Indian state of Kerala.
Thandre N Gopinath, K P Lakshmi, P C Shaji, P C Rajalakshmi   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source