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ADOPTIVE IMMUNOTHERAPY IN CANINE CHIMERAS1

Transplantation, 1997
Chimerism and tolerance after bone marrow transplantation provide excellent conditions for adoptive immunotherapy with T cells of the marrow donor. We studied adoptive immunotherapy in dog leukocyte antigen-identical canine littermate chimeras. Mixed chimeras were produced by conditioning treatment with total body irradiation of a dose of 10 Gy, a ...
Michael Schumm   +5 more
openaire   +3 more sources

Adoptive immunotherapy of HCMV infection

Cytotherapy, 2007
Human cytomegalovirus (HCMV) infection or reactivation is a frequent cause of morbidity and mortality in immunocompromised individuals such as transplant recipients. Primary HCMV infection or reactivation of HCMV from latency is mostly asymptomatic in immunocompetent individuals and is controlled by the host's cell-mediated immune response.
Götz Ulrich Grigoleit   +3 more
openaire   +3 more sources

Enhancing adoptive immunotherapy of cancer

Expert Opinion on Biological Therapy, 2010
Conventional therapies, including surgery, chemotherapy and radiotherapy have contributed much to cancer treatment. However, these treatment modalities fail in a large proportion of patients, and there is a great need for effective alternate therapies.
Phillip K. Darcy   +6 more
openaire   +3 more sources

Mononuclear Cell Adoptive Immunotherapy

Hematology/Oncology Clinics of North America, 1994
In contrast with red cells, platelets, and granulocytes, hemotherapy using lymphocytes and monocytes is only beginning to be explored. Blood banks and transfusion services, the traditional sources of expertise in sterile cell processing, storage, and transfusion, have played an integral role in the early technical development of mononuclear cell ...
Harvey G. Klein, Jong-Hoon Lee
openaire   +3 more sources

Adoptive Immunotherapy of Melanoma

2011
Adoptive immunotherapy involves the ex vivo manipulation and expansion of lymphocytes to treat cancer. These lymphocytes, or effector cells, are “adoptively” transferred into the recipient and may be infused alone or as part of a regimen that includes chemotherapy, radiation therapy, exogenous cytokines and/or other biologic agents (e.g., antibodies ...
Seth M. Pollack, Cassian Yee
openaire   +2 more sources

T-Cell Adoptive Immunotherapy

2004
Adoptive transfer originally referred to the ability to confer protective immunity on a naive host via infusion of T lymphocytes from an immune donor. This term now also encompasses a strategy of cancer therapy in which autologous T cells are acquired from a tumor-bearing host then activated and numerically expanded ex vivo prior to reinfusion.
Gregory E. Plautz   +3 more
openaire   +2 more sources

Adoptive Immunotherapy of Advanced Melanoma

Current Treatment Options in Oncology, 2012
Adoptive cell therapy (ACT) has emerged as an effective therapy for patients with metastatic melanoma. Since the first introduction of the protocol in 1988 [1], major improvements have been achieved with response rates of 40%-72% among patients who were resistant to previous treatment lines.
Ronnie Shapira-Frommer   +2 more
openaire   +3 more sources

Costimulatory approaches to adoptive immunotherapy

Current Opinion in Oncology, 1998
Costimulation is critical for induction of full T-cell effector function, and thus represents an attractive immunotherapeutic approach for the treatment of cancer. This review examines these approaches, including ex vivo T-cell expansion, systemic "delivery" of constimulation, tumors transduced or transfected with costimulatory ligands, and vaccine ...
Carl H. June   +2 more
openaire   +3 more sources

Adoptive immunotherapy for herpesviruses

2007
Herpesvirus infections rarely cause significant problems in the immunocompetent human host. However, in the immunosuppressed, for example, recipients of hematopoietic stem cell transplants (HSCT) (Rooney et al., 1998), solid organ transplants (SOT), or human immunodeficiency virus (HIV)-infected individuals, viral infections/reactivations are common ...
Catherine M. Bollard   +3 more
openaire   +2 more sources

Technological advances in adoptive immunotherapy

Drugs of Today, 2005
Adoptive immunotherapy is an attractive and elegant strategy for treating a variety of life-threatening diseases. Several approaches have been developed to generate antigen-specific CD4+ and CD8+ T cells for adoptive T-cell therapy in cancer and infectious diseases.
Christine Krueger   +2 more
openaire   +3 more sources

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