Results 31 to 40 of about 327,034 (336)

TCR Gene Therapy: Challenges, Opportunities, and Future Directions

Cells, 2020
Adoptive immunotherapy with gene-engineered T cells has provided new treatment options for cancer patients [...]
Hans J. Stauss, Maxine G. B. Tran
doaj   +1 more source

Enhancement of the antigen-specific cytotoxic T lymphocyte-inducing ability in the PMDC11 leukemic plasmacytoid dendritic cell line via lentiviral vector-mediated transduction of the caTLR4 gene. [PDF]

, 2015
The aim of the present study was to enhance the efficiency of leukemia immunotherapy by increasing the antigen-specific cytotoxic T lymphocyte-inducing ability of leukemia cells. The leukemic plasmacytoid dendritic cell line PMDC05 containing the HLA-A02/
Bonehill, Aude, Hashimoto, Shigeo, Iwabuchi, Minami, Iwaya, Shunpei, Kasahara, Noriyuki, Narita, Miwako, Nishizawa, Yoshinori, Oiwa, Eri, Takahashi, Masuhiro, Takizawa, Jun, Uchiyama, Takayoshi   +10 more
core   +1 more source

Lung cancer immunotherapy: progress, pitfalls, and promises

Molecular Cancer, 2023
Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include surgery, radiation therapy, chemotherapy, and targeted drug therapy.
Aritraa Lahiri, Avik Maji, P. Potdar, Navneet Singh, P. Parikh, B. Bisht, Anubhab Mukherjee, M. Paul   +7 more
semanticscholar   +1 more source

Adoptive Immunotherapy in Postoperative Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis.

PLoS ONE, 2016
BackgroundAdoptive immunotherapy (AI) has been applied in the treatment of non-small-cell lung cancer (NSCLC) patients, but the value of postoperative AI has been inconclusive largely as a result of the small number of patients included in each study. We
Yuan Zeng, Wenli Ruan, Jiaxi He, Jianrong Zhang, Wenhua Liang, Yaoqi Chen, Qihua He, Jianxing He   +7 more
doaj   +1 more source

Adoptive Immunotherapy for Cancer or Viruses [PDF]

Annual Review of Immunology, 2014
Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. The application of the principles of synthetic biology to enhance T cell function has resulted in substantial increases in clinical efficacy.
Michael Kalos, Bruce L. Levine, Joseph A. Fraietta, Carl H. June, Yangbing Zhao, Marcela V. Maus   +5 more
openaire   +3 more sources

Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12 [PDF]

, 2011
Immunotherapy-based strategies for gastrointestinal carcinomas (GIC) have been exploited so far, but these approaches have to face strong mechanisms of immune escape induced by tumours.
Alaniz, Almand, Appay, Barajas, Bell, Beyer, Bluestone, Brodsky, Bronte, Caruso, Catalina Atorrasagasti, Clark, Colombo, Colvin, Croci, Curiel, Dieckmann, Elkord, Ferlay, Flavia Piccioni, Gabrilovich, Gabrilovich, Ghiringhelli, Ghiringhelli, Gomez, Guillermo Mazzolini, Haigh, Huang, Jaime A. Espinoza, Jorge B. Aquino, Juan Bayo, Kerkar, Ko, Larmonier, Laura Alaniz, Leonard, Lorenz, Malvicini, Manuel Gidekel, Mariana Garcia, Mariana Ingolotti, Mariana Malvicini, Matar, Mazzolini, Mazzolini, Mazzolini, Medina-Echeverz, Melero, Nestle, O. Graciela Scharovsky, Onishi, Ormandy, Pablo Matar, Proietti, Putzer, Rabinovich, Sakaguchi, Sangro, Shapira, Spaapen, Suzuki, Takahashi, Tang, Thornton, Trinchieri, Vignali, Yokoyama, Zou, Zou, Zwirner   +69 more
core   +1 more source

Adoptive Natural Killer Cell Immunotherapy for Canine Osteosarcoma

Frontiers in Veterinary Science, 2021
Osteosarcoma is the most common primary bone tumor in both humans and dogs. It is a highly metastatic cancer and therapy has not improved significantly since the inclusion of adjuvant chemotherapy into disease treatment strategies.
William C. Kisseberth, Dean A. Lee
doaj   +1 more source

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Nature reviews. Immunology, 2020
The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a central focus for engaging the immune system in the fight against cancer.
A. Waldman, Jill M. Fritz, M. Lenardo
semanticscholar   +1 more source

Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma

Frontiers in Oncology, 2020
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with very poor prognosis and few advances in its treatment. Recently, fast-growing cancer immunotherapy provides a glimmer of hope for GBM treatment.
Jingyu Wang, F. Shen, Ying Yao, Lin-lin Wang, Yongjian Zhu, Jue Hu   +5 more
semanticscholar   +1 more source

Combined therapy with cytokine-induced killer cells and oncolytic adenovirus expressing IL-12 induce enhanced antitumor activity in liver tumor model. [PDF]

PLoS ONE, 2012
Both adoptive immunotherapy and gene therapy hold a great promise for treatment of malignancies. However, these strategies exhibit limited anti-tumor activity, when they are used alone.
Zhi Yang, Qianzhen Zhang, Ke Xu, Juanjuan Shan, Junjie Shen, Limei Liu, Yanmin Xu, Feng Xia, Ping Bie, Xia Zhang, Youhong Cui, Xiu-Wu Bian, Cheng Qian   +12 more
doaj   +1 more source