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The Application of iPSCs in Tumour Immunotherapy
Expert Reviews in Molecular MedicineBackground Tumour immunotherapy holds great promise as a treatment for cancer, which ranks as the second highest cause of mortality worldwide. This therapeutic approach can be broadly categorized into two main types: active immunotherapy and passive or ...
Peinan Chen +8 more
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The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]
, 2019 Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua +4 more
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Adoptive T-Cell Immunotherapy [PDF]
, 2015 Epstein-Barr virus (EBV) is associated with a range of malignancies involving B cells, T cells, natural killer (NK) cells, epithelial cells, and smooth muscle. All of these are associated with the latent life cycles of EBV, but the pattern of latency-associated viral antigens expressed in tumor cells depends on the type of tumor.
Stephen, Gottschalk, Cliona M, Rooney
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The State of Cellular Adoptive Immunotherapy for Neuroblastoma and Other Pediatric Solid Tumors
Frontiers in Immunology, 2017 Research on adult cancer immunotherapy is proceeding at a rapid pace resulting in an impressive success rate exemplified by a few high profile cases. However, this momentum is not readily extended to pediatric immunotherapy, and it is not for lack of ...
Thanh-Phuong Le, To-Ha Thai
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Immunotherapy, Inflammation and Colorectal Cancer. [PDF]
, 2020 Colorectal cancer (CRC) is the third most common cancer type, and third highest in mortality rates among cancer-related deaths in the United States.
Karin, Michael +3 more
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Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
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Application of Immunotherapy in Hepatocellular Carcinoma
Frontiers in Oncology, 2021 Hepatocellular carcinoma is one of the most common malignancies globally. It not only has a hidden onset but also progresses rapidly. Most HCC patients are already in the advanced stage of cancer when they are diagnosed, and have even lost the ...
Lele Miao +7 more
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Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]
, 2016 Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D. +8 more
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Chimeric Antigen Receptor T Cell Therapy in Hematology
Turkish Journal of Hematology, 2015 It is well demonstrated that the immune system can control and eliminate cancer cells. Immune-mediated elimination of tumor cells has been discovered and is the basis of both cancer vaccines and cellular therapies including hematopoietic stem cell ...
Pınar Ataca, Önder Arslan
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Vaccines, 2022 Neoantigens are abnormal proteins produced by genetic mutations in somatic cells. Because tumour neoantigens are expressed only in tumour cells and have immunogenicity, they may represent specific targets for precision immunotherapy.
Lei Gao, Anqi Zhang, Fuyuan Yang, Wei Du
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