Results 61 to 70 of about 327,034 (336)

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

Molecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source

Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting

Nature Communications, 2021
KRAS is commonly mutated at codon 12 in several cancer types, offering a unique opportunity for the development of neoantigen-targeted immunotherapy. Here the authors present a pipeline for the prediction, identification and validation of HLA class-I ...
Adham S. Bear, Tatiana Blanchard, Joseph Cesare, Michael J. Ford, Lee P. Richman, Chong Xu, Miren L. Baroja, Sarah McCuaig, Christina Costeas, Khatuna Gabunia, John Scholler, Avery D. Posey, Mark H. O’Hara, Anze Smole, Daniel J. Powell, Benjamin A. Garcia, Robert H. Vonderheide, Gerald P. Linette, Beatriz M. Carreno   +18 more
doaj   +1 more source

Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells.

Blood, 2019
Chimeric antigen receptor (CAR) T cells have emerged as a promising class of cell-based immunotherapy in refractory malignancies. Neurotoxicity represents a common and potentially life-threatening adverse effect of CAR T cells, and clinical experience is
P. Karschnia, P. Karschnia, J. Jordan, D. Forst, I. Arrillaga-Romany, T. Batchelor, J. Baehring, Nathan F. Clement, L. Castro, A. Herlopian, M. Maus, Michaela H. Schwaiblmair, J. Soumerai, R. Takvorian, E. Hochberg, J. Barnes, J. Abramson, M. Frigault, J. Dietrich   +18 more
semanticscholar   +1 more source

Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients [PDF]

, 2013
Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients
Klingebiel, Thomas, Lehrnbecher, Thomas, Schmidt, Stanislaw, Tramsen, Lars   +3 more
core   +2 more sources

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Novel Immunotherapeutic Approach in Gastric Cancer

Acta Medica Bulgarica, 2020
Gastric cancer (GC) is suitable for immunotherapy because 80% of it display microsatellite and chromosomal instability, some mutations and DNA hypermethylation. Therefore, GC is more immunogenic.
Gulubova M., Hadzhi M., Ignatova M., Chonov D., Balakan O., Aydan M., Ananiev J.   +6 more
doaj   +1 more source

Cancer immunotherapies: advances and bottlenecks

Frontiers in Immunology, 2023
Immunotherapy has ushered in a new era in cancer treatment, and cancer immunotherapy continues to be rejuvenated. The clinical goal of cancer immunotherapy is to prime host immune system to provide passive or active immunity against malignant tumors ...
Rui Rui, Rui Rui, Rui Rui, Rui Rui, Liqun Zhou, Liqun Zhou, Liqun Zhou, Liqun Zhou, Shiming He, Shiming He, Shiming He, Shiming He   +11 more
doaj   +1 more source

Natural Killer Cells as Allogeneic Effectors in Adoptive Cancer Immunotherapy

Cancers, 2019
Natural killer (NK) cells are attractive within adoptive transfer settings in cancer immunotherapy due to their potential for allogeneic use; their alloreactivity is enhanced under conditions of killer immunoglobulin-like receptor (KIR) mismatch with ...
Kyle B. Lupo, S. Matosevic
semanticscholar   +1 more source

Immune evasion in cancer: mechanistic basis and therapeutic strategies [PDF]

, 2015
Cancer immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Although considerable progress has been made in understanding how cancers evade destructive immunity, measures to counteract tumor escape have not ...
Amin, Amr, Aquilano, Katia, Ashraf, S. Salman, Azmi, Asfar S., Bhakta, Dipita, Bilsland, Alan, Boosani, Chandra S., Chen, Sophie, Choi, Beom K., Ciriolo, Maria Rosa, Decker, William K., Elkord, Eyad, Fujii, Hiromasa, Georgakilas, Alexandros G., Guha, Gunjan, Halicka, Dorota, Helferich, William G., Honoki, Kanya, Keith, W. Nicol, Kumara, H.M.C. Shantha, Kwona, Byoung S., Lichtor, Terry, Mohammed, Sulma I., Nowsheen, Somaira, Pawelec, Graham, Ryan, Elizabeth P., Signori, Emanuela, Stagg, John, Talib, Wamidh H., Vinay, Dass S., Whelan, Richard L., Yang, Xujuan   +31 more
core   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source