Results 91 to 100 of about 944,744 (294)
PDE4D drives rewiring of the MAPK pathway in BRAF-mutated melanoma resistant to MAPK inhibitors
Cell Communication and SignalingBackground Phosphodiesterase type 4D (PDE4D) breaks down cyclic AMP (cAMP) reducing the signaling of this intracellular second messenger which plays a major role in melanocyte pathophysiology. In advanced melanoma, expression of PDE4D is increased, plays
Julie Delyon +8 more
doaj +1 more source
Debates in allergy medicine: Specific immunotherapy in children with atopic dermatitis, the "con" view. [PDF]
, 2016 Atopic dermatitis (AD) is a common chronic skin condition in children that has a proven association with other atopic conditions and allergies. These associations, like the general pathophysiology of AD, are complex and not fully understood.
Eichenfield, Lawrence F +1 more
core +3 more sources
The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one [PDF]
, 2018 In renal cancer emerging treatment options are becoming available and there is a strong need to combine therapies to reformulate and adjourn clinical practice.
Botticelli, A. +4 more
core +1 more source
Role of dendritic cells in the induction of lymphocyte tolerance
Frontiers in Immunology, 2015 The ability of dendritic cells (DCs) to trigger tolerance or immunity is dictated by the context in which an antigen is encountered. A large body of evidence indicates that antigen presentation by steady-state DCs induces peripheral tolerance through ...
Fabiola eOsorio +4 more
doaj +1 more source
Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic
Annals of Oncology, 2018 Background Treatment with immune checkpoint blockade (ICB) with agents such as anti-programmed cell death protein 1 (PD-1), anti-programmed death-ligand 1 (PD-L1), and/or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) can result in impressive ...
T. Chan +6 more
semanticscholar +1 more source
Journal of Immunology Research, 2023 Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma +4 more
doaj +1 more source
Współczesna Onkologia, 2018 The immunotherapy is currently changing the landscape of oncology. Nowadays the standard of care in metastatic or unresectable melanoma patients include immunomodulating modalities such as anti-PD-1 drugs (nivolumab, pembrolizumab) and anti-CTLA-4 antibody ipilimumab.
Paweł Teterycz +2 more
openaire +2 more sources
Cancer immunotherapy as a new treatment option [PDF]
, 2019 Cancer can coaptate the immune control of the immune system (IS), evade immunity and its destruction. So, could we say openly that immunotherapy is a viable treatment option for patients with advanced cancer?
Alonso-Ortiz, Antonio +2 more
core
Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies
Journal for ImmunoTherapy of Cancer, 2018 Mutation-derived neoantigens represent an important class of tumour-specific, tumour rejection antigens, and are attractive targets for TCR gene therapy of cancer.
Vanessa M. Tubb +9 more
doaj +1 more source
Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]
, 2016 Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D. +8 more
core +2 more sources