Results 101 to 110 of about 867,189 (360)

Conformational landscape of HIV-1 Env from closed to fully open

Nature Communications
The molecular mechanism of HIV-1 entry into host cells is governed by dynamic conformational changes to its envelope glycoprotein (Env), which are triggered by the engagement of the host receptor CD4 and coreceptors.
Jiayan Cui, Zi Jie Lin, Sukanya Ghosh, Jianqiu Du, Roopak Sadeesh, David B. Weiner, Jesper Pallesen   +6 more
doaj   +1 more source

Understanding nucleic acid sensing and its therapeutic applications

Experimental and Molecular Medicine, 2023
Nucleic acid sensing is involved in viral infections, immune response-related diseases, and therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as DNA or RNA sensors.
Ling-Zu Kong, Seok-Min Kim, Chunli Wang, Soo Yun Lee, Se-Chan Oh, Sunyoung Lee, Seona Jo, Tae-Don Kim   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PDE4D drives rewiring of the MAPK pathway in BRAF-mutated melanoma resistant to MAPK inhibitors

Cell Communication and Signaling
Background Phosphodiesterase type 4D (PDE4D) breaks down cyclic AMP (cAMP) reducing the signaling of this intracellular second messenger which plays a major role in melanocyte pathophysiology. In advanced melanoma, expression of PDE4D is increased, plays
Julie Delyon, Selma Becherirat, Anissa Roger, Mélanie Bernard-Cacciarella, Coralie Reger De Moura, Baptiste Louveau, Samia Mourah, Céleste Lebbé, Nicolas Dumaz   +8 more
doaj   +1 more source

Hypoxia increases melanoma-associated fibroblasts immunosuppressive potential and inhibitory effect on T cell-mediated cytotoxicity

OncoImmunology, 2021
Cancer-associated fibroblasts (CAFs) and hypoxia are central players in the complex process of tumor cell-stroma interaction and are involved in the alteration of the anti-tumor immune response by impacting both cancer and immune cell populations ...
Linda Ziani, Stéphanie Buart, Salem Chouaib, Jerome Thiery   +3 more
doaj   +1 more source

Advances on immunotherapy for osteosarcoma

Molecular Cancer
Osteosarcoma is the most common primary bone cancer in children and young adults. Limited progress has been made in improving the survival outcomes in patients with osteosarcoma over the past four decades.
Shengnan Yu, Xudong Yao
semanticscholar   +1 more source

Effect of specific immunotherapy added to pharmachologic treatment and allergen avoidance in allergic asthma

, 2004
Although several studies support the efficacy of specific immunotherapy in allergic asthma, its benefit compared with that of standardized pharmacologic intervention remains unknown.
PIACENTINI, Giorgio, Maestrelli P., Zanolla L, on behalf of the Regione Veneto Study Group on the ‘‘Effect of immunotherapy in allergic asthma’’, Fabbri L, Pozzan M   +5 more
core   +1 more source

Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer

, 2023
Breast cancer (BC) is a representative malignant tumor that affects women across the world, and it is the main cause of cancer-related deaths in women. Although a large number of treatment methods have been developed for BC in recent years, the results ...
Xiaoyi Zhang, Hongzhou Cai, Junying Zhang, Yun Hu, Fenglin Huang, Yan Li, Zhangcheng Yao, Hanyuan Liu   +7 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer

Molecular Cancer
Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is more challenging and may be unresponsive to conventional therapy.
Moumita Kundu, R. Butti, Venketesh K Panda, Diksha Malhotra, Sumit Das, Tandrima Mitra, Prachi Kapse, Suresh W. Gosavi, G. C. Kundu   +8 more
semanticscholar   +1 more source