Results 81 to 90 of about 786,579 (199)

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]

, 2018
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core   +1 more source

Amplifying STING activation by bioinspired nanomedicine for targeted chemo- and immunotherapy of acute myeloid leukemia

, 2022
Xiaoqi Wang, Ruihao Huang, Wei Wu, Jingkang Xiong, Wen Qin, Yunjing Zeng, Ting Chen, Jiali Li, Cheng Zhang, Jiang F. Zhong, Shijie Yang, Xi Zhang   +11 more
openalex   +1 more source

Pre-therapeutic lymphocytopenia: a new prognostic factor for failure of endovesical BCG-immunotherapy in non-muscle invasive bladder cancer [PDF]

, 2023
Idriss Ziani, Ahmed Ibrahimi, Omar Bellouki, Hachem Elsayegh, Rédouane Abouqal, Yassine Nouini, Amal Bouziane   +6 more
openalex   +1 more source

OA19.06 CRTAM Acts as a Checkpoint of Immune-related Adverse Events Uncoupling Efficacy and Toxicity During Immunotherapy [PDF]

, 2023
Si-Cong Ma, Zi-Xuan Rong, Jr‐Rung Lin, Dafei Han, X.-T. Cai, Zhong‐Yi Dong   +5 more
openalex   +1 more source

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. [PDF]

, 2019
Glioblastoma is the most common primary malignant brain tumor in adults and is associated with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a randomized, multi-institution clinical trial to evaluate immune responses ...
Arrillaga-Romany, Isabel C, Butowski, Nicholas A, Clarke, Jennifer L, Cloughesy, Timothy F, Cohen, Adam L, Colman, Howard, Davidson, Tom B, de Groot, John F, Du, Lin, Ellingson, Benjamin M, Gaffey, Sarah C, Hugo, Willy, Kaley, Thomas J, Kawaguchi, Eric S, Lee, Alexander H, Lee, Eudocia Q, Li, Gang, Liau, Linda M, Mellinghoff, Ingo K, Mochizuki, Aaron Y, Nghiemphu, Phioanh L, O'Brien, Barbara J, Orpilla, Joey R, Prins, Robert M, Reardon, David A, Rytlewski, Julie A, Sanders, Catherine M, Wang, Anthony C, Wen, Patrick Y, Yong, William H   +29 more
core  

Chimeric Antigen Receptor (CAR) T Cells Releasing Soluble SLAMF6 Isoform 2 Gain Superior Anti-Cancer Cell Functionality in an Auto-Stimulatory Fashion

Cells
T cells equipped with chimeric antigen receptors (CARs) have evolved into an essential pillar of lymphoma therapy, reaching second-line treatment. In solid cancers, however, a dearth of lasting CAR T cell activation poses the major obstacle to achieving ...
Dennis Christoph Harrer, Tim Schlierkamp-Voosen, Markus Barden, Hong Pan, Maria Xydia, Wolfgang Herr, Jan Dörrie, Niels Schaft, Hinrich Abken   +8 more
doaj   +1 more source

Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

Journal for ImmunoTherapy of Cancer, 2018
Mutation-derived neoantigens represent an important class of tumour-specific, tumour rejection antigens, and are attractive targets for TCR gene therapy of cancer.
Vanessa M. Tubb, Deborah S. Schrikkema, Nathan P. Croft, Anthony W. Purcell, Carsten Linnemann, Manon R. Freriks, Frederick Chen, Heather M. Long, Steven P. Lee, Gavin M. Bendle   +9 more
doaj   +1 more source

Loop Catalog: a comprehensive HiChIP database of human and mouse samples

Genome Biology
HiChIP enables cost-effective and high-resolution profiling of chromatin loops. To leverage the increasing number of HiChIP datasets, we develop Loop Catalog ( https://loopcatalog.lji.org ), a web-based database featuring loop calls from over 1000 ...
Joaquin Reyna, Kyra Fetter, Romeo Ignacio, Cemil Can Ali Marandi, Astoria Ma, Nikhil Rao, Zichen Jiang, Daniela Salgado Figueroa, Sourya Bhattacharyya, Ferhat Ay   +9 more
doaj   +1 more source

Tandem CAR-T cells targeting mesothelin and MUC16 overcome tumor heterogeneity by targeting one antigen at a time

Journal for ImmunoTherapy of Cancer
Background Tumor heterogeneity and antigen escape are mechanisms of resistance to chimeric antigen receptor (CAR)-T cell therapy, especially in solid tumors.
Eugene Kim, Marcela V Maus, Alexander Armstrong, Amanda A Bouffard, Mark B Leick, Christopher Kelly, Giulia Escobar, Filippo Birocchi, Diego Salas-Benito, Tamina Kienka, Sangwoo Park, Cassidy E Ho, Aiyana L Parker, Jessica A Frank, Kiana Graham, Sadie Goncalves, Bo Rueda, Trisha R Berger   +17 more
doaj   +1 more source

Therapeutic potential of hyporesponsive CD4+ T cells in autoimmunity

Frontiers in Immunology, 2015
The interaction between dendritic cells (DCs) and T cells is crucial on immunity or tolerance induction. In an immature or semi-mature state, DCs induce tolerance through T cell deletion, generation of regulatory T cells and/or induction of T cell anergy.
Jaxaira eMaggi, Jaxaira eMaggi, Carolina eSchäfer, Carolina eSchäfer, Gabriela eUbilla-Olguín, Gabriela eUbilla-Olguín, Diego eCatalan, Diego eCatalan, Katina eSchinnerling, Katina eSchinnerling, Juan C Aguillon, Juan C Aguillon   +11 more
doaj   +1 more source