Results 61 to 70 of about 537,211 (318)

Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease

Communications Biology
Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease affecting the central nervous system (CNS) in animals that parallels several clinical and molecular traits of multiple sclerosis in humans.
Luisa F. Duarte, Verónica Villalobos, Mónica A. Farías, Ma. Andreina Rangel-Ramírez, Enrique González-Madrid, Areli J. Navarro, Javier Carbone-Schellman, Angélica Domínguez, Alejandra Alvarez, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis, Mónica Cáceres, Pablo A. González   +13 more
doaj   +1 more source

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

Nature Communications, 2017
γδ T cells are generally considered innate‐like lymphocytes. Here the authors sequence human γδ T cell receptors (TCR) to show focusing of the private Vδ1 TCR repertoire, suggesting that, unlike Vδ2 T cells, the Vδ1 T cell compartment has adaptive ...
Martin S. Davey, Carrie R. Willcox, Stephen P. Joyce, Kristin Ladell, Sofya A. Kasatskaya, James E. McLaren, Stuart Hunter, Mahboob Salim, Fiyaz Mohammed, David A. Price, Dmitriy M. Chudakov, Benjamin E. Willcox   +11 more
doaj   +1 more source

The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers [PDF]

, 2022
As the indications for the use of immunotherapy in genitourinary malignancies expand, its role in combination with standard or conventional therapies has become the subject of contemporary studies.
Isabella Dolendo, Rana R. McKay, Aditya Bagrodia, Ava Saidian, Amirali Salmasi, Brent Rose, Andrew Sharabi, Tyler F. Stewart   +7 more
core   +1 more source

Immunoglobulin Depletion and Recovery Following Blinatumomab in Infants With KMT2A‐Rearranged ALL

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Adding blinatumomab to standard chemotherapy for infants with KMT2A‐rearranged acute B‐cell lymphoblastic leukemia (KMT2A‐r B‐ALL) improves outcomes. Although blinatumomab impairs immunoglobulin G (lgG) production, increasing infection susceptibility, IgG recovery remains poorly understood.
Miguel Vieira Martins, Paola de Lorenzo, Rishi S. Kotecha, Andishe Attarbaschi, Gabriele Escherich, Karsten Nysom, Jan Stary, Alina Ferster, Benoit Brethon, Franco Locatelli, Martin Schrappe, Peggy E. Scholte‐van Houtem, Maria G. Valsecchi, Rob Pieters, Inge M. van der Sluis   +14 more
wiley   +1 more source

Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion

Cancer Immunology, Immunotherapy
Background Lymphocyte antigen 6 complex, locus E (Ly6E) has been initially demonstrated to involve in T cell activity and impair viral infectivity. Recently, high expression levels of Ly6E have been reported in tumor microenvironment (TME) of various ...
Lan Hailin, Chen Yiting, Wu Yue, Li Lijun, Zhang Renlu, Chen Yunhan, Zhu Yanyang, Zhang Qiuyu   +7 more
doaj   +1 more source

Cancer Immunotherapy

Molecular Oncology, 1999
The remarkable specificity of the immune system through antigen recognition has long attracted investigators to the possibility of immune‐based therapy for cancer. Previous cancer immunotherapeutics had been restricted to non‐specific immunomodulatory agents, such as the cytokines IL‐2 or IFN‐α.
openaire   +3 more sources

Development of a technology for arranged electrofusion of mammalian cells : applicability in breast cancer immunotherapy [PDF]

, 2007
Schaper J. Development of a technology for arranged electrofusion of mammalian cells : applicability in breast cancer immunotherapy. Bielefeld (Germany): Bielefeld University; 2007.Cellular immunotherapy of cancer is a hot topic ever since the discovery ...
Schaper, J., Schaper, Janina
core   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors. [PDF]

, 2012
Glioblastoma multiforme is the most common and aggressive malignant brain tumor in humans, and the prognosis is very poor despite conventional therapy.
Sara Fritzell, Eberstål, Sofia,, Siesjö, Peter, Anna Darabi, Sofia Eberstål, Peter Siesjö, Fritzell, Sara, Magnus Esbjörnsson, Edward Visse, Visse, Edward, Siesjö, Peter,, Darabi, Anna,, Badn, Wiaam, Esbjörnsson, Magnus, Visse, Edward,, Darabi, Anna, Wiaam Badn, Eberstål, Sofia, Fritzell, Sara,, Badn, Wiaam,, Lund University.   +20 more
core   +1 more source

Hope and Hype around Immunotherapy in Triple-Negative Breast Cancer [PDF]

, 2023
Triple-negative breast cancer (TNBC) holds a poor prognosis compared to other breast cancer subtypes, and the development of new effective treatment strategies is an unmet medical need.
Alberto Zambelli, Elisa Agostinetto, Armando Santoro, Rita De Sanctis, Flavia Jacobs, Chiara Miggiano   +5 more
core   +1 more source