Results 51 to 60 of about 230,496 (168)

Immunotherapy for atherosclerosis [PDF]

Physiological Reviews
Cardiovascular disease is the global #1 cause of mortality and morbidity. The majority of cardiovascular diseases is caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The disease is characterized by the formation of atherosclerotic plaques throughout the arterial tree.
Claudia Monaco, Coleen A. McNamara, Bram Slütter, Amanda C. Foks, Stefan Bekiranov, Willem J.M. Mulder, Isabel Gonçalves, Esther Lutgens   +7 more
openaire   +4 more sources

Insufficient ferroptosis in radiation-induced tumor cells promote Treg cell generation to induce radiotherapy resistance

Communications Biology
Recently, cellular mechanisms underlying radioresistance in the tumor microenvironment (TME) attract increasing attention, but how the resistant tumor cells reshape the TME is still unclear. In this study, we find that the ferroptosis-resistant genes are
Yue Wu, Yanyang Zhu, Chang Yu, Yuchen Yu, Yi Luo, Yi Zhang, Yonglei Xiao, Qiuyu Zhang   +7 more
doaj   +1 more source

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

Nature Communications, 2017
γδ T cells are generally considered innate‐like lymphocytes. Here the authors sequence human γδ T cell receptors (TCR) to show focusing of the private Vδ1 TCR repertoire, suggesting that, unlike Vδ2 T cells, the Vδ1 T cell compartment has adaptive ...
Martin S. Davey, Carrie R. Willcox, Stephen P. Joyce, Kristin Ladell, Sofya A. Kasatskaya, James E. McLaren, Stuart Hunter, Mahboob Salim, Fiyaz Mohammed, David A. Price, Dmitriy M. Chudakov, Benjamin E. Willcox   +11 more
doaj   +1 more source

Development of a technology for arranged electrofusion of mammalian cells : applicability in breast cancer immunotherapy [PDF]

, 2007
Schaper J. Development of a technology for arranged electrofusion of mammalian cells : applicability in breast cancer immunotherapy. Bielefeld (Germany): Bielefeld University; 2007.Cellular immunotherapy of cancer is a hot topic ever since the discovery ...
Schaper, J., Schaper, Janina
core  

The Gut Microbiome and Cancer Immunotherapy: Can We Use the Gut Microbiome as a Predictive Biomarker for Clinical Response in Cancer Immunotherapy?

, 2021
Background: Emerging evidence suggests that gut microbiota influences the clinical response to immunotherapy. This review of clinical studies examines the relationship between gut microbiota and immunotherapy outcomes.
Susan Carroll, Michael Back, George Hruby, Nick Pavlakis, Frances Boyle, Mark Stevens, Wen Liu, Benjamin Kong, Andrew Kneebone, Mark Molloy, Stephen Clarke, Thomas Eade, Brian Corless, Gillian Lamoury, Marita Morgia, Byeongsang Oh, Towia Libermann, David Rosenthal   +17 more
core   +1 more source

Cancer Immunotherapy

Molecular Oncology, 1999
The remarkable specificity of the immune system through antigen recognition has long attracted investigators to the possibility of immune‐based therapy for cancer. Previous cancer immunotherapeutics had been restricted to non‐specific immunomodulatory agents, such as the cytokines IL‐2 or IFN‐α.
openaire   +3 more sources

Immunotherapy in Solid Tumors and Gut Microbiota: The Correlation—A Special Reference to Colorectal Cancer

, 2020
Over the last few years, immunotherapy has been considered as a key player in the treatment of solid tumors. Immune checkpoint inhibitors (ICIs) have become the breakthrough treatment, with prolonged responses and improved survival results.
John Tsiaoussis, Ippokratis Messaritakis, Nikolaos Gouvas, Asimina Koulouridi, John Souglakos   +4 more
core   +1 more source

Electroporation and Immunotherapy—Unleashing the Abscopal Effect

, 2022
SIMPLE SUMMARY: Electrochemotherapy and irreversible electroporation are primarily used for treating patients with cutaneous and subcutaneous tumors and pancreatic cancer, respectively.
Nolsoe, Christian, Adile Orhan, Raskov, Hans, Orhan, Adile, Hans Raskov, Justesen, Tobias Freyberg, Gögenur, Ismail, Tobias Freyberg Justesen, Ismail Gögenur, Christian Nolsoe   +9 more
core   +1 more source

Autonomic modulation of the immune response and implications for CNS malignancies

npj Precision Oncology
While the central nervous system (CNS) has long been known to regulate global physiologic processes, its role in regulating immune responses has only relatively recently been appreciated.
Lucas P. Wachsmuth, Ethan S. Srinivasan, Bhairavy J. Puviindran, Aden P. Haskell-Mendoza, Tyrone DeSpenza, Peter E. Fecci   +5 more
doaj   +1 more source

The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets

Nature Communications, 2018
Human Vδ2+ γδ T cells are thought to be an innate-like T-cell population. Here the authors show the Vδ2+ compartment contains both innate-like Vγ9+ and an adaptive Vγ9- subset that undergoes clonal expansion during viral infection and can infiltrate ...
Martin S. Davey, Carrie R. Willcox, Stuart Hunter, Sofya A. Kasatskaya, Ester B. M. Remmerswaal, Mahboob Salim, Fiyaz Mohammed, Frederike J. Bemelman, Dmitriy M. Chudakov, Ye H. Oo, Benjamin E. Willcox   +10 more
doaj   +1 more source