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Lung cancer immunotherapy: progress, pitfalls, and promises
Molecular Cancer, 2023 Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include surgery, radiation therapy, chemotherapy, and targeted drug therapy.
Aritraa Lahiri +7 more
semanticscholar +1 more source
Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1
Journal for ImmunoTherapy of Cancer, 2019 Background Several predictive biomarkers are currently approved or are under investigation for the selection of patients for checkpoint blockade. Tumor PD-L1 expression is used for stratification of non-small cell lung (NSCLC) patients, with tumor ...
Kellie N. Smith +40 more
doaj +1 more source
The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration
Nature Communications, 2023 As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from environmental ...
Emilie J. Cosway +7 more
doaj +1 more source
CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy
Nature, 2019 Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin–granzyme and Fas–Fas ligand ...
Weimin Wang +29 more
semanticscholar +1 more source
NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE [PDF]
, 2014 There are an estimated 18 million Alzheimer’s disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Teeling, Jessica L. +5 more
core +1 more source
The Renewal of Cancer Immunotherapy
, 2023 Cancer immunotherapy embraces many current, promising therapeutic approaches to eradicate tumors by activating host antitumor activity [...
Jenny Bulgarelli +3 more
core +1 more source
Macrophages as regulators of tumor immunity and immunotherapy
Nature reviews. Immunology, 2019 Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis.
D. DeNardo, B. Ruffell
semanticscholar +1 more source
Intralymphatic immunotherapy [PDF]
World Allergy Organization Journal, 2015 Gold Standard allergen-specific immunotherapy is associated with low efficacy because it requires either many subcutaneous injections of allergen or even more numerous sublingual allergen administrations to achieve amelioration of symptoms. Intralymphatic vaccination can maximize immunogenicity and hence efficacy.
Senti G, Kündig TM
openaire +4 more sources
, 2020 In the last few decades, cancer immunotherapy becomes an important tactic for cancer treatment. However, some immunotherapy shows certain limitations including poor therapeutic targeting and unwanted side effects that hinder its use in clinics. Recently,
Tilahun Ayane Debele +2 more
core +1 more source
Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic
OncoImmunology, 2023 BO-112 is a poly I:C-based viral mimetic that exerts anti-tumor efficacy when intratumorally delivered in mouse models. Intratumoral BO-112 synergizes in mice with systemic anti-PD-1 mAbs and this combination has attained efficacy in PD1-refractory ...
Maite Alvarez +16 more
doaj +1 more source