Results 21 to 30 of about 867,189 (360)

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Cellular & Molecular Immunology, 2020
Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and immune checkpoint inhibitors (ICIs), have obtained durable clinical responses, but
Yuanyuan Zhang, Zemin Zhang
semanticscholar   +1 more source

CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells

Frontiers in Immunology, 2023
Chimeric antigen receptors (CARs) in the canonical “second generation” format provide two signals for inducing T cell effector functions; the primary “signal-1” is provided through the TCR CD3ζ chain and the “signal-2” through a linked costimulatory ...
Simone Thomas, Simone Thomas, Hinrich Abken, Hinrich Abken   +3 more
doaj   +1 more source

Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer

Nature Communications, 2022
HIV envelope is a target for vaccine development, but induction of broadly neutralizing antibodies has been difficult. Here, the authors show that electroporation with a synthetic DNA vaccine construct allows in vivo production of HIV envelope native ...
Ziyang Xu, Susanne Walker, Megan C. Wise, Neethu Chokkalingam, Mansi Purwar, Alan Moore, Edgar Tello-Ruiz, Yuanhan Wu, Sonali Majumdar, Kylie M. Konrath, Abhijeet Kulkarni, Nicholas J. Tursi, Faraz I. Zaidi, Emma L. Reuschel, Ishaan Patel, April Obeirne, Jianqiu Du, Katherine Schultheis, Lauren Gites, Trevor Smith, Janess Mendoza, Kate E. Broderick, Laurent Humeau, Jesper Pallesen, David B. Weiner, Daniel W. Kulp   +25 more
doaj   +1 more source

B cells and tertiary lymphoid structures promote immunotherapy response

Nature, 2020
Treatment with immune checkpoint blockade (ICB) has revolutionized cancer therapy. Until now, predictive biomarkers1–10 and strategies to augment clinical response have largely focused on the T cell compartment.
Beth A. Helmink, S. Reddy, Jian-Jun Gao, Shaojun Zhang, R. Başar, R. Thakur, K. Yizhak, M. Sade-Feldman, J. Blando, Guangchun Han, V. Gopalakrishnan, Y. Xi, Hao Zhao, R. Amaria, H. Tawbi, Alexandria P. Cogdill, Wen-Bin Liu, V. LeBleu, Fernanda G. Kugeratski, S. Patel, M. Davies, P. Hwu, Jeffrey E. Lee, J. Gershenwald, A. Lucci, R. Arora, S. Woodman, E. Keung, P. Gaudreau, A. Reuben, C. Spencer, E. Burton, L. Haydu, A. Lazar, Roberta Zapassodi, C. Hudgens, Debora A. Ledesma, Sufey Ong, M. Bailey, Sarah Warren, Disha Rao, O. Krijgsman, E. Rozeman, D. Peeper, C. Blank, T. Schumacher, L. Butterfield, M. Zelazowska, Kevin M. McBride, R. Kalluri, J. Allison, F. Petitprez, W. Fridman, C. Sautès-Fridman, N. Hacohen, K. Rezvani, Padmanee Sharma, M. Tetzlaff, Linghua Wang, J. Wargo   +59 more
semanticscholar   +1 more source

Immunotherapy of lung cancer: An update [PDF]

, 2006
In Germany lung cancer is the leading cause of cancer-associated death in men. Surgery, chemotherapy and radiation may enhance survival of patients suffering from lung cancer but the enhancement is typically transient and mostly absent with advanced ...
Hatz, R. A., Jauch, Karl-Walter, van den Engel, N.K., Fox, B.A., Grützner, S., Hatz, R.A., Rüttinger, D., Fox, B. A., Jauch, K.-W., Winter, H., van den Engel, N. K., Schendel, D. J., Pohlac, H., Pohla, H., Schlemmer, M., Schendel, D.J.   +15 more
core   +1 more source

In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection [PDF]

, 1987
We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that in vivo application of recombinant human IL-2 (rhIL-2) can enhance the antiviral effect of a limited number of CD8+T lymphocytes, not only in ...
Reddehase, Matthias J., W Mutter, Koszinowski, Ulrich H., Wolfgang Mutter, J. Reddehase, M J Reddehase, U H Koszinowski, Koszinowski, Ulrich, Mutter, Wolfgang, Ulrich H. Koszinowski   +9 more
core   +2 more sources

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

Science, 2017
Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade ...
V. Gopalakrishnan, C. Spencer, L. Nezi, A. Reuben, M. Andrews, T. Karpinets, P. Prieto, D. Vicente, K. Hoffman, S. Wei, Alexandria P. Cogdill, L. Zhao, C. Hudgens, D. Hutchinson, T. Manzo, M. Petaccia de Macedo, T. Cotechini, T. Kumar, W. Chen, S. Reddy, R. S. Szczepaniak Sloane, J. Galloway-Peña, H. Jiang, P. Chen, E. Shpall, K. Rezvani, A. Alousi, R. Chemaly, S. Shelburne, L. Vence, P. Okhuysen, V. Jensen, A. Swennes, F. McAllister, E. Marcelo Riquelme Sanchez, Y. Zhang, E. Le Chatelier, L. Zitvogel, N. Pons, J. Austin-Breneman, L. Haydu, E. Burton, J. Gardner, E. Sirmans, J. Hu, A. Lazar, T. Tsujikawa, A. Diab, H. Tawbi, I. Glitza, W. Hwu, S. Patel, S. Woodman, R. Amaria, M. Davies, J. Gershenwald, P. Hwu, J. Lee, J. Zhang, L. Coussens, Z. Cooper, P. A. Futreal, C. Daniel, N. Ajami, J. Petrosino, M. Tetzlaff, P. Sharma, J. Allison, R. Jenq, J. Wargo   +69 more
semanticscholar   +1 more source

A systematic review and economic evaluation of subcutaneous and sublingual allergen immunotherapy in adults and children with seasonal allergic rhinitis [PDF]

, 2013
© Queen’s Printer and Controller of HMSO 2013Severe allergic rhinitis uncontrolled by conventional medication can substantially affect quality of life. Immunotherapy involves administering increasing doses of a specific allergen, with the aim of reducing
B Kaambwa, P Barton, Barton, P, J Dretzke, Kaambwa, B, A Huissoon, Novielli, N, C Meads, A Meadows, A Fry-Smith, Dretzke, J, Huissoon, A, N Novielli, Fry-Smith, A, Meads, C, Meadows, A   +15 more
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Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Nature Medicine, 2018
Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical benefits, but only a fraction of patients respond to treatment. To predict ICB response, we developed TIDE, a computational method to model two primary mechanisms of ...
Peng Jiang, Sheng-Qing Gu, D. Pan, Jingxin Fu, Avinash Sahu, Xihao Hu, Ziyi Li, Nicole Traugh, Xia Bu, Bo Li, Bo Li, Jun Liu, G. Freeman, Myles A. Brown, K. Wucherpfennig, X. Liu   +15 more
semanticscholar   +1 more source

An escherichia coli vaccine co-expressing listeriolysin-O and tumour antigen in cancer immunotherapy and the mechanisms of immune regulation [PDF]

, 2009
PhDSome recombinant bacterial strains have been shown to be very efficient in experimental therapies against cancer in rodent models. Amongst them is an E. coli that expresses the Listeriolysin-O protein (LLO) and a model tumour antigen ovalbumin (OVA)
Dai, Ming-Shen
core   +4 more sources