Results 11 to 20 of about 230,496 (168)

Oncolytic Virus Immunotherapy

, 2021
Oncolytic viruses (OVs) were originally developed as direct cytotoxic agents but have been increasingly recognised as a form of immunotherapy [...
Carolina S. Ilkow, Antonio Marchini, Alan Melcher, Marchini, A, Ilkow, CS, Melcher, A   +5 more
core   +1 more source

Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer

Nature Communications, 2022
HIV envelope is a target for vaccine development, but induction of broadly neutralizing antibodies has been difficult. Here, the authors show that electroporation with a synthetic DNA vaccine construct allows in vivo production of HIV envelope native ...
Ziyang Xu, Susanne Walker, Megan C. Wise, Neethu Chokkalingam, Mansi Purwar, Alan Moore, Edgar Tello-Ruiz, Yuanhan Wu, Sonali Majumdar, Kylie M. Konrath, Abhijeet Kulkarni, Nicholas J. Tursi, Faraz I. Zaidi, Emma L. Reuschel, Ishaan Patel, April Obeirne, Jianqiu Du, Katherine Schultheis, Lauren Gites, Trevor Smith, Janess Mendoza, Kate E. Broderick, Laurent Humeau, Jesper Pallesen, David B. Weiner, Daniel W. Kulp   +25 more
doaj   +1 more source

Immunotherapy of lung cancer: An update [PDF]

, 2006
In Germany lung cancer is the leading cause of cancer-associated death in men. Surgery, chemotherapy and radiation may enhance survival of patients suffering from lung cancer but the enhancement is typically transient and mostly absent with advanced ...
Hatz, R. A., Jauch, Karl-Walter, van den Engel, N.K., Fox, B.A., Grützner, S., Hatz, R.A., Rüttinger, D., Fox, B. A., Jauch, K.-W., Winter, H., van den Engel, N. K., Schendel, D. J., Pohlac, H., Pohla, H., Schlemmer, M., Schendel, D.J.   +15 more
core   +1 more source

Immunotherapy of lymphomas [PDF]

Journal of Clinical Investigation, 2020
Lymphoid malignancies typically promote an infiltrate of immune cells at sites involved by the disease. While some of the immune cells present in lymphoma have effector function, the immune system is unable to eradicate the malignant clone. Therapies that optimize immune function therefore have the potential to improve the outcome of lymphoma patients.
Stephen M, Ansell, Yi, Lin
openaire   +2 more sources

Modulation of Endosome Function, Vesicle Trafficking and Autophagy by Human Herpesviruses

Cells, 2021
Human herpesviruses are a ubiquitous family of viruses that infect individuals of all ages and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad spectrum of diseases, ranging from skin and mucosal lesions to blindness ...
Eduardo I. Tognarelli, Antonia Reyes, Nicolás Corrales, Leandro J. Carreño, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González   +6 more
doaj   +1 more source

Immunotherapy [PDF]

OncoImmunology, 2012
The Janus-faced roles of macrophages in cancer imply both tumor-suppressive and -stimulating actions of these innate immune cells. Whereas the balance is toward tumor promotion in most epithelial cancers, we have recently shown that osteosarcoma metastasis seems to be inhibited by macrophages. Here we discuss the possible mechanism of this observation.
Cleton-Jansen, A.M., Buddingh, E.P., Lankester, A.C.   +2 more
openaire   +3 more sources

Recent Advances and Challenges in Cancer Immunotherapy

, 2022
SIMPLE SUMMARY: Immunotherapy helps a person’s immune system to target tumor cells. Recent advances in cancer immunotherapy, including immune checkpoint inhibition, chimeric antigen receptor T-cell therapy and cancer vaccination, have changed the ...
Yiping Yang, Peterson, Chelsea, Denlinger, Nathan, Chelsea Peterson, Nathan Denlinger, Yang, Yiping   +5 more
core   +1 more source

Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators

, 2020
In the last few decades, cancer immunotherapy becomes an important tactic for cancer treatment. However, some immunotherapy shows certain limitations including poor therapeutic targeting and unwanted side effects that hinder its use in clinics. Recently,
Tilahun Ayane Debele, Wen-Pin Su, Cheng-Fa Yeh   +2 more
core   +1 more source

Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer

, 2023
Breast cancer (BC) is a representative malignant tumor that affects women across the world, and it is the main cause of cancer-related deaths in women. Although a large number of treatment methods have been developed for BC in recent years, the results ...
Xiaoyi Zhang, Hongzhou Cai, Junying Zhang, Yun Hu, Fenglin Huang, Yan Li, Zhangcheng Yao, Hanyuan Liu, Huang, Fenglin, Liu, Hanyuan, Cai, Hongzhou, Yao, Zhangcheng, Hu, Yun, Zhang, Junying, Li, Yan, Zhang, Xiaoyi   +15 more
core   +1 more source

Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo

Nature Communications, 2022
Plasma B cells (PC) are a potential source for protein replacement as they could be engineered to secrete protein other than antibody. Here the authors engineer B cells to express exogenous proteins and demonstrate that these cells can persist long term ...
Rene Yu-Hong Cheng, King L. Hung, Tingting Zhang, Claire M. Stoffers, Andee R. Ott, Emmaline R. Suchland, Nathan D. Camp, Iram F. Khan, Swati Singh, Ying-Jen Yang, David J. Rawlings, Richard G. James   +11 more
doaj   +1 more source