Results 1 to 10 of about 15,641 (165)

Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments [PDF]

Frontiers in Immunology, 2018
Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to xanthosine monophosphate, the rate-limiting step in de novo guanosine monophosphate (GMP) synthesis.
S. John Calise, Georges Abboud, Hideko Kasahara, Laurence Morel, Edward K. L. Chan   +4 more
doaj   +5 more sources

The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress [PDF]

eLife, 2014
The ‘ribosomal stress (RS)-p53 pathway’ is triggered by any stressor or genetic alteration that disrupts ribosomal biogenesis, and mediated by several ribosomal proteins (RPs), such as RPL11 and RPL5, which inhibit MDM2 and activate p53.
Qi Zhang, Xiang Zhou, RuiZhi Wu, Amber Mosley, Shelya X Zeng, Zhen Xing, Hua Lu   +6 more
doaj   +6 more sources

Identification of IMP Dehydrogenase as a Potential Target for Anti-Mpox Virus Agents [PDF]

Microbiology Spectrum, 2023
Mpox virus (formerly monkeypox virus [MPXV]) is a neglected zoonotic pathogen that caused a worldwide outbreak in May 2022. Given the lack of an established therapy, the development of an anti-MPXV strategy is of vital importance.
Takayuki Hishiki, Takeshi Morita, Daisuke Akazawa, Hirofumi Ohashi, Eun-Sil Park, Michiyo Kataoka, Junki Mifune, Kaho Shionoya, Kana Tsuchimoto, Shinjiro Ojima, Aa Haeruman Azam, Shogo Nakajima, Madoka Kawahara, Tomoki Yoshikawa, Masayuki Shimojima, Kotaro Kiga, Ken Maeda, Tadaki Suzuki, Hideki Ebihara, Yoshimasa Takahashi, Koichi Watashi   +20 more
doaj   +2 more sources

In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors [PDF]

Nature Communications, 2020
Trypanosoma brucei inosine-5′-monophosphate dehydrogenase (IMPDH) is an enzyme in the guanine nucleotide biosynthesis pathway and of interest as a drug target.
Karol Nass, Lars Redecke, M. Perbandt, O. Yefanov, M. Klinge, R. Koopmann, F. Stellato, A. Gabdulkhakov, R. Schönherr, D. Rehders, J. M. Lahey-Rudolph, A. Aquila, A. Barty, S. Basu, R. B. Doak, R. Duden, M. Frank, R. Fromme, S. Kassemeyer, G. Katona, R. Kirian, H. Liu, I. Majoul, J. M. Martin-Garcia, M. Messerschmidt, R. L. Shoeman, U. Weierstall, S. Westenhoff, T. A. White, G. J. Williams, C. H. Yoon, N. Zatsepin, P. Fromme, M. Duszenko, H. N. Chapman, C. Betzel   +35 more
doaj   +2 more sources

Specific biotinylation of IMP dehydrogenase. [PDF]

Bioorg Med Chem Lett, 2011
IMP dehydrogenase (IMPDH) catalyzes a critical step in guanine nucleotide biosynthesis. IMPDH also has biological roles that are distinct from its enzymatic function. We report a biotin-linked reagent that selectively labels IMPDH and is released by dithiothreitol. This reagent will be invaluable in elucidating the moonlighting functions of IMPDH.
Hoefler BC, Gollapalli DR, Hedstrom L.
europepmc   +4 more sources

Substrate cooperativity shapes competitive inhibitor responses in mycobacterial inosine 5′-monophosphate dehydrogenase [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Inosine 5′-monophosphate dehydrogenase (IMPDH) is a promising antimicrobial target due to its central role in guanine nucleotide biosynthesis. Accurate and reliable kinetic measurements are essential for evaluating inhibitors.
Zdeněk Knejzlík, Ondřej Bulvas, Matteo Dedola, Milan Štefek, Radim Nencka, Iva Pichová   +5 more
doaj   +2 more sources

IMP dehydrogenase: structure, mechanism, and inhibition. [PDF]

Chem Rev, 2009
George Weber was among the first to recognize that extensive metabolic changes must underlie the unbridled proliferation of cancer cells 1. His molecular correlation hypothesis postulated that a defined set of key “pace-maker” enzymes are stringently linked to neoplastic transformation and progression, and that inhibition of these enzymes would provide
Hedstrom L.
europepmc   +4 more sources

ALDH3A1-dependent Nrf2/HO-1/GPX4 pathway supports AHR as a promising therapeutic target for ferroptosis and promotes imperatorin-mediated lung protection [PDF]

Cell Death Discovery
The aryl hydrocarbon receptor (AHR) is a transcription factor prominently expressed at barrier sites, while aldehyde dehydrogenase 3 family member A1 (ALDH3A1) is a metabolic enzyme implicated in oxidative stress.
Xiaominting Song, Wenya Yang, Hang You, Shan Qian, Xiaoxue Hu, Ao Zhang, Jia Li, Yuzhi Li, Huachao Bin, Cheng Peng, Jin Pei, Zhixing Cao   +11 more
doaj   +2 more sources

The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors. [PDF]

Curr Med Chem, 2011
Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the first committed step of guanosine 5'-monophosphate (GMP) biosynthesis, and thus regulates the guanine nucleotide pool, which in turn governs proliferation. Human IMPDHs are validated targets for immunosuppressive, antiviral and anticancer drugs, but as yet microbial IMPDHs have not been ...
Hedstrom L, Liechti G, Goldberg JB, Gollapalli DR.   +3 more
europepmc   +4 more sources

Changes in Umami-Enhancing Nucleotides in White Mullet (Ophiocephalus argus var. Kimnra) Meat Stored at Ice Temperature [PDF]

Foods
The aim of this study was to investigate the effect of ice-temperature (IT) storage on the umami-enhancing nucleotide content in white mullet (Ophiocephalus argus var. Kimnra) meat.
Yin Zhang, Qing Li, Qing Zeng, Hongling Hu, Longyi Zhang, Li Dong, Jiao Zhou, Yuzhu Lin   +7 more
doaj   +2 more sources